ArticleSchizophrenia research2011
Alcohol use disorders contribute to hippocampal and subcortical shape differences in schizophrenia.
Article in Schizophrenia research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Variation in fourteen brain structure volumes in schizophrenia: A comprehensive meta-analysis of 246 studies.Neuroscience and biobehavioral reviews · 2019Pooled it
- Problematic alcohol use and reduced hippocampal volume: a meta-analytic review.Psychological medicine · 2017Pooled it
- Brain Structural Effects of Antipsychotic Treatment in Schizophrenia: A Systematic Review.Current neuropharmacology · 2015Pooled it
- Concomitant pathologies and their impact on schizophrenia: a narrative overview of current evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Axis I Psychiatric Disorders and Substance Abuse: A Systematic Review of Neuroimaging Findings.Journal of clinical medicine · 2025Review
- Functional and Structural Brain Abnormalities and Clinical Characteristics of Male Patients with Alcohol Dependence.Brain sciences · 2023Article
- Incomplete Hippocampal Inversion: A Neurodevelopmental Mechanism for Hippocampal Shape Deformation in Schizophrenia.Biological psychiatry · 2022Article
- Article
- Neuroimaging Studies in Patients With Mental Disorder and Co-occurring Substance Use Disorder: Summary of Findings.Frontiers in psychiatry · 2019Review
- The Risk Factors of the Alcohol Use Disorders-Through Review of Its Comorbidities.Frontiers in neuroscience · 2018Review
- Age-related differences in the structural complexity of subcortical and ventricular structures.Neurobiology of aging · 2017Article
- Progressive deterioration of thalamic nuclei relates to cortical network decline in schizophrenia.Schizophrenia research · 2017Article
- Subcomponents of brain T2* relaxation in schizophrenia, bipolar disorder and siblings: A Gradient Echo Plural Contrast Imaging (GEPCI) study.Schizophrenia research · 2015Article
- Association study identifying a new susceptibility gene (AUTS2) for schizophrenia.International journal of molecular sciences · 2014Article
- An FMRI study of the influence of a history of substance abuse on working memory-related brain activation in schizophrenia.Frontiers in psychiatry · 2014Article
- Longitudinal progression of frontal and temporal lobe changes in schizophrenia.Schizophrenia research · 2012Article
- Are cardiovascular risk factors associated with verbal learning and memory impairment in patients with schizophrenia? A cross-sectional study.Cardiovascular psychiatry and neurology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlcohol abuse and dependence have been reported to exacerbate the clinical course of schizophrenia. However, the neurobiological basis of this co-morbid interaction is unknown. The aim of this study was to determine the relationship of co-morbid alcohol use disorder (AUD) with brain structure abnormalities in schizophrenia patients.
methodsT1-weighted magnetic resonance images were collected from schizophrenia patients without a history of any substance use disorder (SCZ_0, n=35), schizophrenia patients with a history of AUD only (SCZ_AUD, n=16), and a healthy comparison group without a history of any substance use disorder (CON, n=56). Large-deformation, high-dimensional brain mapping was used to quantify the surface shapes of the hippocampus, thalamus, striatum, and globus pallidus in these subject groups. Analysis of variance was used to test for differences in surface shape measures among the groups.
resultsSCZ_AUD demonstrated the greatest severity of shape abnormalities in the hippocampus, thalamus, striatum, and globus pallidus as compared to SCZ_0 and CON. SCZ_AUD demonstrated a combination of exaggerated shape differences in regions where SCZ_0 also showed shape differences, and unique shape differences that were not observed in SCZ_0 or CON.
conclusionsShape differences in schizophrenia were compounded by a history of co-morbid AUD. Future research is needed to determine whether these differences are simply additive or whether they are due to an interaction between the underlying neurobiology of schizophrenia and alcoholism. The consequences of such shape differences for the clinical course of schizophrenia are not yet understood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.