ArticleBiomaterials2011
Functionalized PEG hydrogels through reactive dip-coating for the formation of immunoactive barriers.
Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Development of zwitterionic hydrogel thin film coatings of cochlear implant electrode arrays that reduce intracochlear inflammation and electrode impedance.Hearing research · 2026Article
- Enzymatic Methods for Assembling and Modifying Hydrogel Biomaterials.Regenerative engineering and translational medicine · 2025Article
- PEG-Based Hydrogel Coatings: Design Tools for Biomedical Applications.Annals of biomedical engineering · 2024Article
- Anti-melanoma effect and action mechanism of a novel chitosan-based composite hydrogel containing hydroxyapatite nanoparticles.Regenerative biomaterials · 2022Article
- Synthesis and characterization of a novel pH-responsive drug-releasing nanocomposite hydrogel for skin cancer therapy and wound healing.Journal of materials chemistry. B · 2021Article
- Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering.Journal of cardiovascular development and disease · 2021Review
- Bioactive hydrogel coatings of complex substrates using diffusion-mediated redox initiation.Journal of materials chemistry. B · 2020Article
- Dual-Enzyme Crosslinking and Post-polymerization for Printing of Polysaccharide-Polymer Hydrogel.Frontiers in chemistry · 2020Article
- Up in the air: oxygen tolerance in controlled/living radical polymerisation.Chemical Society reviews · 2018Review
- Rapid Fabrication of Cell-Laden Alginate Hydrogel 3D Structures by Micro Dip-Coating.Frontiers in bioengineering and biotechnology · 2017Article
- Antioxidant cerium oxide nanoparticle hydrogels for cellular encapsulation.Acta biomaterialia · 2015Article
- Recent advances in crosslinking chemistry of biomimetic poly(ethylene glycol) hydrogels.RSC advances · 2015Article
- Device design and materials optimization of conformal coating for islets of Langerhans.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Biomechanics and mechanobiology in functional tissue engineering.Journal of biomechanics · 2014Review
- Interfacial thiol-ene photoclick reactions for forming multilayer hydrogels.ACS applied materials & interfaces · 2013Article
- Formation of Core-Shell Particles by Interfacial Radical Polymerization Initiated by a Glucose Oxidase-Mediated Redox System.Chemistry of materials : a publication of the American Chemical Society · 2013Article
- Redox Initiation of Bulk Thiol-Ene Polymerizations.Polymer chemistry · 2013Article
- Kinetics of interfacial radical polymerization initiated by a glucose-oxidase mediated redox system.Biomaterials · 2012Article
- Strategies to reduce dendritic cell activation through functional biomaterial design.Biomaterials · 2012Article
- PEG hydrogels formed by thiol-ene photo-click chemistry and their effect on the formation and recovery of insulin-secreting cell spheroids.Biomaterials · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Influencing the host immune system via implantable cell-delivery devices has the potential to reduce inflammation at the transplant site and increase the likelihood of tissue acceptance. Towards this goal, an enzymatically-initiated, dip-coating technique is adapted to fabricate conformal hydrogel layers and to create immunoactive polymer coatings on cell-laden poly(ethylene glycol) (PEG) hydrogels. Glucose oxidase (GOx)-initiated dip coatings enable the rapid formation of uniform, PEG-based coatings on the surfaces of PEG hydrogels, with thicknesses up to 500 μm where the thickness is proportional to the reaction time. Biofunctional coatings were fabricated by thiolating biomolecules that were subsequently covalently incorporated into the coating layer via thiol-acrylate copolymerization. The presence of these proteins was verified via fluorescent confocal microscopy and a modified ELISA, which indicated IgG concentrations as high as 13 ± 1 ng/coated cm² were achievable. Anti-Fas antibody, known to induce T cell apoptosis, was incorporated into coatings, with or without the addition of ICAM-1 to promote T cell interaction with the functionalized coating. Jurkat T cells were seeded atop functionalized coatings and the induction of apoptosis was measured as an indicator of coating bioactivity. After 48 h of interaction with the functionalized coatings, 61 ± 9% of all cells were either apoptotic or dead, compared to only 18 ± 5% of T cells on non-functionalized coatings. Finally, the cytocompatibility of the surface-initiated GOx coating process was confirmed by modifying gels with either encapsulated β-cells or 3T3 fibroblasts within a gel that contained a PEG methacrylate coating.
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Registered trials
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