ArticleJournal of the American College of Cardiology2011
Sonic hedgehog-induced functional recovery after myocardial infarction is enhanced by AMD3100-mediated progenitor-cell mobilization.
Article in Journal of the American College of Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- From gene to mechanics: a comprehensive insight into the mechanobiology of LMNA mutations in cardiomyopathy.Cell communication and signaling : CCS · 2024Review
- Partial Mural Cell Ablation Disrupts Coronary Vasculature Integrity and Induces Systolic Dysfunction.Journal of the American Heart Association · 2023Article
- Gli1 promotes the phenotypic transformation of valve interstitial cells through Hedgehog pathway activation exacerbating calcific aortic valve disease.International journal of biological sciences · 2023Article
- Signaling pathways and targeted therapy for myocardial infarction.Signal transduction and targeted therapy · 2022Review
- Review
- Sonic Hedgehog upregulation does not enhance the survival and engraftment of stem cell-derived cardiomyocytes in infarcted hearts.PloS one · 2020Article
- Cardioprotective effect of sonic hedgehog ligand in pig models of ischemia reperfusion.Theranostics · 2020Article
- Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice.International journal of molecular medicine · 2019Article
- Role of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance.International journal of molecular sciences · 2019Review
- Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine.International journal of molecular sciences · 2018Review
- Sonic hedgehog promotes endothelial differentiation of bone marrow mesenchymal stem cells via VEGF-D.Journal of thoracic disease · 2018Article
- PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway.Respiratory research · 2018Article
- Review
- Hh signaling in regeneration of the ischemic heart.Cellular and molecular life sciences : CMLS · 2017Review
- Circulating fibrocyte mobilization in negative pressure wound therapy.Journal of cellular and molecular medicine · 2017Article
- In smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor.Respiratory research · 2017Article
- New strategies for improving stem cell therapy in ischemic heart disease.Heart failure reviews · 2016Review
- Article
- Enhancing endothelial progenitor cell for clinical use.World journal of stem cells · 2015Article
- Hedgehog and Resident Vascular Stem Cell Fate.Stem cells international · 2015Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 4 countries.
Funding
Abstract
objectivesThis study was designed to compare the effectiveness of Sonic hedgehog (Shh) gene transfer, AMD3100-induced progenitor-cell mobilization, and Shh-AMD3100 combination therapy for treatment of surgically induced myocardial infarction (MI) in mice.
backgroundShh gene transfer improves myocardial recovery by up-regulating angiogenic genes and enhancing the incorporation of bone marrow-derived progenitor cells (BMPCs) in infarcted myocardium. Here, we investigated whether the effectiveness of Shh gene therapy could be improved with AMD3100-induced progenitor-cell mobilization.
methodsGene expression and cell function were evaluated in cells cultured with medium collected from fibroblasts transfected with plasmids encoding human Shh (phShh). MI was induced in wild-type mice, in matrix metalloproteinase (MMP)-9 knockout mice, and in mice transplanted with bone marrow that expressed green-fluorescent protein. Mice were treated with 100 μg of phShh (administered intramyocardially), 5 mg/kg of AMD3100 (administered subcutaneously), or both; cardiac function was evaluated echocardiographically, and fibrosis, capillary density, and BMPC incorporation were evaluated immunohistochemically.
resultsphShh increased vascular endothelial growth factor and stromal cell-derived factor 1 expression in fibroblasts; the medium from phShh-transfected fibroblasts increased endothelial-cell migration and the migration, proliferation, and tube formation of BMPCs. Combination therapy enhanced cardiac functional recovery (i.e., left ventricular ejection fraction) in wild-type mice, but not in MMP-9 knockout mice, and was associated with less fibrosis, greater capillary density and smooth muscle-containing vessel density, and enhanced BMPC incorporation.
conclusionsCombination therapy consisting of intramyocardial Shh gene transfer and AMD3100-induced progenitor-cell mobilization improves cardiac functional recovery after MI and is superior to either individual treatment for promoting therapeutic neovascularization.
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Registered trials
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