ArticleNeuroImage2011
Atlas-based investigation of human brain tissue microstructural spatial heterogeneity and interplay between transverse relaxation time and radial diffusivity.
Article in NeuroImage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Spatial Image Gradient Estimation From the Diffusion MRI Profile.Magnetic resonance in medicine · 2026Article
- Spatial image gradient estimation from the diffusion MRI profile.bioRxiv : the preprint server for biology · 2025Article
- Peripheral Nerve Involvement in Friedreich's Ataxia Characterized by Quantitative Magnetic Resonance Neurography.European journal of neurology · 2025Article
- Quantification and Proximal-to-Distal Distribution Pattern of Tibial Nerve Lesions in Relapsing-Remitting Multiple Sclerosis : Assessment by MR Neurography.Clinical neuroradiology · 2023Article
- Microstructural mapping of dentate gyrus pathology in Alzheimer's disease: A 16.4 Tesla MRI study.NeuroImage. Clinical · 2023Article
- Magnetic Resonance Neurography: Improved Diagnosis of Peripheral Neuropathies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Diffusion tensor imaging of the human cerebellar pathways and their interplay with cerebral macrostructure.Frontiers in neuroanatomy · 2015Article
- Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients.PloS one · 2015Article
- DTI-based segmentation and quantification of human brain lateral ventricular CSF volumetry and mean diffusivity: validation, age, gender effects and biophysical implications.Magnetic resonance imaging · 2014Article
- Development of superficial white matter and its structural interplay with cortical gray matter in children and adolescents.Human brain mapping · 2014Article
- Relationship between T2 relaxation and apparent diffusion coefficient in malignant and non-malignant prostate regions and the effect of peripheral zone fractional volume.The British journal of radiology · 2013Article
- Article
- Diffusion tensor quantification and cognitive correlates of the macrostructure and microstructure of the corpus callosum in typically developing and dyslexic children.NMR in biomedicine · 2012Article
- Multi-modal quantitative MRI investigation of brain tissue neurodegeneration in multiple sclerosis.Journal of magnetic resonance imaging : JMRI · 2012Article
- Human brain atlas-based multimodal MRI analysis of volumetry, diffusimetry, relaxometry and lesion distribution in multiple sclerosis patients and healthy adult controls: implications for understanding the pathogenesis of multiple sclerosis and consolidation of quantitative MRI results in MS.Journal of the neurological sciences · 2012Article
- Multimodal quantitative magnetic resonance imaging of thalamic development and aging across the human lifespan: implications to neurodegeneration in multiple sclerosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Microstructural metrics obtained using magnetic resonance imaging (MRI) such as transverse relaxation time and radial diffusivity have been used as in vivo markers of human brain tissue integrity. Considering the sensitivity of these parameters to some common biophysical contributors and their structural and spatial heterogeneity, we hypothesized that strong inter and intra-regional associations exist between these variables providing evidence to possible interplay between transverse relaxation time and radial diffusivity. To validate our hypothesis we obtained high resolution anatomical T1-weighted data and fused it with T2-relaxometry and diffusion tensor imaging (DTI) data on a cohort of healthy adults. The anatomical data were parcellated using FreeSurfer and then coaligned and fused with the T2 and DTI maps. Our data reveal some association between transverse relaxation and radial diffusivity that may help toward the interpretation and modeling of the biophysical contributors to the measured MRI metrics.
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Registered trials
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