Trial reportTrials2011
The challenges and opportunities of conducting a clinical trial in a low resource setting: the case of the Cameroon mobile phone SMS (CAMPS) trial, an investigator initiated trial.
Trial report in Trials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03394456 (Technology to Improve the Health of Resource-poor Hispanics With Diabetes), which is not on this map. Cited by 38 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Technology to Improve the Health of Resource-poor Hispanics With Diabetes
Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Operational complexities in international clinical trials: a systematic review of challenges and proposed solutions.BMJ open · 2024Pooled it
- Oncology research in Saudi Arabia over a 10-year period. A synopsis.Saudi medical journal · 2020Pooled it
- Barriers for conducting clinical trials in developing countries- a systematic review.International journal for equity in health · 2018Pooled it
- Pooled it
- The IHAT-GUT Iron Supplementation Trial in Rural Gambia: Barriers, Facilitators, and Benefits.Nutrients · 2021Trial
- An evaluation of methods to improve the reporting of adherence in a placebo gel trial in Andhra Pradesh, India.AIDS and behavior · 2013Trial
- Implementation of good clinical practice in clinical research in the context of limited resources settings: Lessons learnt from the freeBILy trial using an embedded mixed methods approach.PLoS neglected tropical diseases · 2026Article
- Awareness, Willingness, and Concerns about Clinical Trial Participation among Iraqi Patients: A Cross-Sectional Study.Global heart · 2026Article
- Unlocking the potential of Contract Research Organizations in Africa's clinical trials ecosystem.Journal of clinical and translational science · 2025Review
- Exploring healthcare workers' perceptions of child health research at Kamuzu Central Hospital, Malawi: an interpretative phenomenological analysis.Human resources for health · 2024Article
- Towards equitable AI in oncology.Nature reviews. Clinical oncology · 2024Review
- Randomised clinical trials in surgery: are we at a crossroads?Annals of medicine and surgery (2012) · 2024Article
- Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP): A Qualitative Study Exploring the Trial Team's Facilitators and Challenges in Conducting a Feasibility Trial in India.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023Article
- Development and implementation of a process evaluation for intervention quality improvement of a community-based behavioral HIV intervention trial in Tanzania.Zeitschrift fur Gesundheitswissenschaften = Journal of public health · 2023Article
- Article
- Strengthening ethics committees for health-related research in sub-Saharan Africa: a scoping review.BMJ open · 2022Article
- Re-engineering a Clinical Trial Management System Using Blockchain Technology: System Design, Development, and Case Studies.Journal of medical Internet research · 2022Article
- Strengthening ethics committees for health-related research in sub-Saharan Africa: a scoping review protocol.BMJ open · 2021Article
- Article
- COVID-19 pandemic: the implications of the natural history, challenges of diagnosis and management for care in sub-Saharan Africa.Beni-Suef University journal of basic and applied sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Conducting clinical trials in developing countries often presents significant ethical, organisational, cultural and infrastructural challenges to researchers, pharmaceutical companies, sponsors and regulatory bodies. Globally, these regions are under-represented in research, yet this population stands to gain more from research in these settings as the burdens on health are greater than those in developed resourceful countries. However, developing countries also offer an attractive setting for clinical trials because they often have larger treatment naive populations with higher incidence rates of disease and more advanced stages. These factors can present a reduction in costs and time required to recruit patients. So, balance needs to be found where research can be encouraged and supported in order to bring maximum public health benefits to these communities. The difficulties with such trials arise from problems with obtaining valid informed consent, ethical compensation mechanisms for extremely poor populations, poor health infrastructure and considerable socio-economic and cultural divides. Ethical concerns with trials in developing countries have received attention, even though many other non-ethical issues may arise. Local investigator initiated trials also face a variety of difficulties that have not been adequately reported in literature. This paper uses the example of the Cameroon Mobile Phone SMS trial to describe in detail, the specific difficulties encountered in an investigator-initiated trial in a developing country. It highlights administrative, ethical, financial and staff related issues, proposes solutions and gives a list of additional documentation to ease the organisational process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.