ArticleJournal of occupational medicine and toxicology (London, England)2011
Screening for tuberculosis and prediction of disease in Portuguese healthcare workers.
Article in Journal of occupational medicine and toxicology (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Risk of Occupational Latent Tuberculosis Infection among Health Personnel Measured by Interferon-Gamma Release Assays in Low Incidence Countries-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Predictive value of interferon-γ release assays for incident active tuberculosis: a systematic review and meta-analysis.The Lancet. Infectious diseases · 2012Pooled it
- Predictive performance of interferon-gamma release assays and the tuberculin skin test for incident tuberculosis: an individual participant data meta-analysis.EClinicalMedicine · 2023Article
- Latent Tuberculosis Infection among Health Workers in Germany-A Retrospective Study on Progression Risk and Use of Preventive Therapy.International journal of environmental research and public health · 2021Article
- Risk Analysis of Latent Tuberculosis Infection among Health Workers Compared to Employees in Other Sectors.International journal of environmental research and public health · 2020Article
- M. tuberculosis infection and antigen specific cytokine response in healthcare workers frequently exposed to tuberculosis.Scientific reports · 2019Article
- Interferon-gamma release assay for the diagnosis of latent tuberculosis infection: A latent-class analysis.PloS one · 2017Article
- Prevalence of latent tuberculosis infection in healthcare workers at a hospital in Naples, Italy, a low-incidence country.Journal of occupational medicine and toxicology (London, England) · 2016Article
- Tuberculin skin test and Quantiferon test agreement and influencing factors in tuberculosis screening of healthcare workers: a systematic review and meta-analysis.Journal of occupational medicine and toxicology (London, England) · 2015Article
- Tuberculosis in healthcare workers - a narrative review from a German perspective.Journal of occupational medicine and toxicology (London, England) · 2014Article
- Occupational screening for tuberculosis and the use of a borderline zone for interpretation of the IGRA in German healthcare workers.PloS one · 2014Article
- Tuberculosis screening at the Sainte-Anne Hospital in Paris - results of first and second IGRA.Journal of occupational medicine and toxicology (London, England) · 2014Article
- Gamma interferon release assays for detection of Mycobacterium tuberculosis infection.Clinical microbiology reviews · 2014Review
- Screening for tuberculosis and the use of a borderline zone for the interpretation of the interferon-γ release assay (IGRA) in Portuguese healthcare workers.Journal of occupational medicine and toxicology (London, England) · 2013Article
- The effect of introducing IGRA to screen French healthcare workers for tuberculosis and potential conclusions for the work organisation.Journal of occupational medicine and toxicology (London, England) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionResults of systematic screening of healthcare workers (HCWs) for tuberculosis (TB) with the tuberculin skin test (TST) and interferon-γ release assays (IGRA) in a Portuguese hospital from 2007 to 2010 are reported.
methodsAll HCWs are offered screening for TB. Screening is repeated depending on risk assessment. TST and QuantiFERON Gold In-Tube (QFT) are used simultaneously. X-ray is performed when TST is > 10 mm, IGRA is positive or typical symptoms exist.
resultsThe cohort comprises 2,889 HCWs. TST and IGRA were positive in 29.5%, TST-positive but IGRA-negative results were apparent in 43.4%. Active TB was diagnosed in twelve HCWs - eight cases were detected during screening and four cases were predicted by IGRA as well as by TST. However, the progression rate in IGRA-positive was higher than in TST-positive HCWs (0.4% vs. 0.2%, p-value 0.06).
conclusionsThe TB burden in this cohort was high (129.8 per 100,000 HCWs). However, the progression to active TB after a positive TST or positive IGRA was considerably lower than that reported in literature for close contacts in low-incidence countries. This may indicate that old LTBI prevails in these HCWs.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.