ArticleFEMS microbiology letters2011
Toxin-antitoxin (TA) systems are prevalent and transcribed in clinical isolates of Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus.
Article in FEMS microbiology letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 58 citations in OpenAlex.
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- The impact of quorum sensing and biofilm formation on antimicrobial resistance and virulence of XDR and MDRIranian journal of veterinary research · 2024Article
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- Evaluation of toxin-antitoxin genes, antibiotic resistance, and virulence genes in Pseudomonas aeruginosa isolates.Revista da Associacao Medica Brasileira (1992) · 2023Article
- DosR's multifaceted role onFrontiers in cellular and infection microbiology · 2023Article
- Characterization of toxin-antitoxin systems from public sequencing data: A case study inFrontiers in microbiology · 2022Article
- Correlation betweenMicroorganisms · 2021Article
- Antibiotic resistance plasmid composition and architecture in Escherichia coli isolates from meat.Scientific reports · 2021Article
- Prophage encoding toxin/antitoxin system PfiT/PfiA inhibits Pf4 production in Pseudomonas aeruginosa.Microbial biotechnology · 2020Article
- The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics.Molecular microbiology · 2019Article
- A switch in the poly(dC)/RmlB complex regulates bacterial persister formation.Nature communications · 2019Article
- Modulation of Toxin-Antitoxin System Rnl AB Type II in Phage-Resistant Gammaproteobacteria Surviving Photodynamic Treatment.Journal of lasers in medical sciences · 2019Review
- Structural Insights Into the Transcriptional Regulation of HigBA Toxin-Antitoxin System by Antitoxin HigA inFrontiers in microbiology · 2019Article
- Article
- Effect of mazEF, higBA and relBE toxin-antitoxin systems on antibiotic resistance in Pseudomonas aeruginosa and Staphylococcus isolates.Malawi medical journal : the journal of Medical Association of Malawi · 2018Article
- Bacterial plasmid addiction systems and their implications for antibiotic drug development.Postdoc journal : a journal of postdoctoral research and postdoctoral affairs · 2017Article
- Diversity, Prevalence, and Longitudinal Occurrence of Type II Toxin-Antitoxin Systems ofFrontiers in microbiology · 2017Article
- Review
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5 authors at 1 institution in 1 country.
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Abstract
The percentage of bacterial infections refractory to standard antibiotic treatments is steadily increasing. Among the most problematic hospital and community-acquired pathogens are methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (PA). One novel strategy proposed for treating infections of multidrug-resistant bacteria is the activation of latent toxins of toxin-antitoxin (TA) protein complexes residing within bacteria; however, the prevalence and identity of TA systems in clinical isolates of MRSA and PA has not been defined. We isolated DNA from 78 MRSA and 42 PA clinical isolates and used PCR to probe for the presence of various TA loci. Our results showed that the genes for homologs of the mazEF TA system in MRSA and the relBE and higBA TA systems in PA were present in 100% of the respective strains. Additionally, reverse transcriptase PCR analysis revealed that these transcripts are produced in the clinical isolates. These results indicate that TA genes are prevalent and transcribed within MRSA and PA and suggest that activation of the toxin proteins could be an effective antibacterial strategy for these pathogens.
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