Evidence map›Paper›PMID 21657973›Full record

ReviewActa orthopaedica2011

Where did bone come from?

Darja Obradovic Wagner, Per Aspenberg

Open access · goldAbstract readReview
In one paragraph

Review in Acta orthopaedica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Crosstalk between bone and other organs.Medical review (2021) · 2022
    Review
  10. Article
  11. The Genome of the "Sea Vomit"Life (Basel, Switzerland) · 2021
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Frogs give new insights into vertebrate novelties.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  17. Review
  18. Mechanism of Bone Mineralization.Cold Spring Harbor perspectives in medicine · 2018
    Review
  19. Review
  20. Evolution of the Marrow Adipose Tissue Microenvironment.Calcified tissue international · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Darja Obradovic WagnerInstitute of Chemistry and Biochemistry , Freie Universität Berlin, Berlin, Germany. darja_obradovic@yahoo.de
Per Aspenberg
Freie Universität Berlin · DELinköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone is specific to vertebrates, and originated as mineralization around the basal membrane of the throat or skin, giving rise to tooth-like structures and protective shields in animals with a soft cartilage-like endoskeleton. A combination of fossil anatomy and genetic information from modern species has improved our understanding of the evolution of bone. Thus, even in man, there are still similarities in the molecular regulation of skin appendages and bone. This article gives a brief overview of the major milestones in skeletal evolution. Some molecular machineries involving members of core genetic networks and their interactions are described in the context of both old theories and modern genetic approaches.

Indexed as

Biological EvolutionBone and BonesCalcification, PhysiologicOsteogenesisBone DevelopmentChondrogenesisHumansSkeleton

Identifiers

PMID21657973
PMCPMC3237026
OpenAlexW2060168413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.