Evidence map›Paper›PMID 21656624›Full record

ArticleAngewandte Chemie (International ed. in English)2011

Synthesis and in vivo fate of zwitterionic near-infrared fluorophores.

Hak Soo Choi, Khaled Nasr, Sergey Alyabyev, Dina Feith, Jeong Heon Lee, Soon Hee Kim, Yoshitomo Ashitate, Hoon Hyun, Gabor Patonay, Lucjan Strekowski and 2 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 198 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
198citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

198 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. More Than a Glow: How Cyanine Dyes Shape Tracer Pharmacokinetics.Angewandte Chemie (International ed. in English) · 2026
    Review
  6. Review
  7. Review: structural determinants of organic dyes for controlling biological clearance pathways.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Review
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138 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hak Soo ChoiDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, SLB-05, Boston, MA 02215, USA.
Khaled Nasr
Sergey Alyabyev
Dina Feith
Jeong Heon Lee
Soon Hee Kim
Yoshitomo Ashitate
Hoon Hyun
Gabor Patonay
Lucjan Strekowski
Maged Henary
John V Frangioni

Funding

Intraoperative Near-Infrared Fluorescence ImagingR01CA115296 · NCI · CURADEL, LLC · PI FRANGIONI, JOHN V · 2005 to 2014
$13.9M
Ultra-Low Background NIR Fluorophores for In Vivo Imaging and Image-Guided SurgerR01EB010022 · NIBIB · CURADEL, LLC · PI FRANGIONI, JOHN V · 2010 to 2013
$2.8M
Image-Guided Surgery of Endocrine Glands and Their Tumors using Near-Infrared FluR01EB011523 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHOI, HAK SOO · 2010 to 2013
$2.0M
NCI NIH HHS R01 CA115296NCI NIH HHS R01-CA-115296NIBIB NIH HHS R01 EB010022NIBIB NIH HHS R01-EB-010022NIBIB NIH HHS R01 EB011523NIBIB NIH HHS R01-EB-011523
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsContrast MediaFluorescent DyesHydrophobic and Hydrophilic InteractionsIndocyanine GreenMaleMiceQuaternary Ammonium CompoundsRatsSpectroscopy, Near-InfraredSulfonic AcidsTissue DistributionContrast MediaFluorescent DyesIndocyanine GreenQuaternary Ammonium CompoundsSulfonic AcidsZW800-1 compoundZW800-3a compound

Identifiers

PMID21656624
PMCPMC3128676

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.