ArticleMagnetic resonance in medicine2011
Quantitative measurement of N-acetyl-aspartyl-glutamate at 3 T using TE-averaged PRESS spectroscopy and regularized lineshape deconvolution.
Article in Magnetic resonance in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Optimal Number of Signal Averages in Stimulated Echo Acquisition Mode for Proton MR Spectroscopy of Brain at 7T.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- Metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: aTranslational psychiatry · 2022Article
- EditedMagnetic resonance in medicine · 2017Review
- Simultaneous quantification of glutamate and glutamine by J-modulated spectroscopy at 3 Tesla.Magnetic resonance in medicine · 2016Article
- Spectral fitting using basis set modified by measured B0 field distribution.NMR in biomedicine · 2015Article
- In vivo assessment of neurotransmitters and modulators with magnetic resonance spectroscopy: application to schizophrenia.Neuroscience and biobehavioral reviews · 2015Review
- Regional and tissue-specific differences in brain glutamate concentration measured by in vivo single voxel MRS.Journal of neuroscience methods · 2015Article
- Smoothness of in vivo spectral baseline determined by mean-square error.Magnetic resonance in medicine · 2014Article
- Measurement of regional variation of GABA in the human brain by optimized point-resolved spectroscopy at 7 T in vivo.NMR in biomedicine · 2014Article
- N-acetyl-aspartyl-glutamate detection in the human brain at 7 Tesla by echo time optimization and improved Wiener filtering.Magnetic resonance in medicine · 2014Article
- In vivo T(2) relaxation time measurement with echo-time averaging.NMR in biomedicine · 2014Article
- Soft constraints in nonlinear spectral fitting with regularized lineshape deconvolution.Magnetic resonance in medicine · 2013Article
- Two-dimensional J-resolved proton MR spectroscopy and prior knowledge fitting (ProFit) in the frontal and parietal lobes of healthy volunteers: assessment of metabolite discrimination and general reproducibility.Journal of magnetic resonance imaging : JMRI · 2013Article
- In vivo detection of 13C isotopomer turnover in the human brain by sequential infusion of 13C labeled substrates.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
This article introduces regularized lineshape deconvolution in conjunction with TE-averaged PRESS spectroscopy to measure N-acetyl-aspartyl-glutamate (NAAG). Averaging different echo times suppressed the signals of multiplets from strongly coupled spin systems near 2 ppm; thus, minimizing the interfering signals to detect the acetyl proton signal of NAAG. Signal distortion was corrected by lineshape deconvolution, and Tikhonov regularization was introduced to reduce noise amplification arising from deconvolution; as a result, spectral resolution was enhanced without significantly sacrificing signal-to-noise ratio (SNR). This new approach was used to measure NAAG in the two regions of interest of healthy volunteers, dominated by gray matter and white matter, respectively. The acetyl proton signal of NAAG was directly quantified by fitting the deconvoluted spectra to a Voigt-lineshape spectral model function, yielding the NAAG-N-acetyl-aspartate (NAA) ratios of 0.11±0.02 for the gray matter voxels (n=8) and 0.18±0.02 for the white matter voxels (n=12).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.