ArticleMagnetic resonance in medicine2012
Automated detection and characterization of SPIO-labeled cells and capsules using magnetic field perturbations.
Article in Magnetic resonance in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Nanoparticle-based T cell immunoimaging and immunomodulatory for diagnosing and treating transplant rejection.Heliyon · 2024Review
- In Vivo Imaging of Naked and Microencapsulated Islet Cell Transplantation.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Magnetic Particle Imaging Is a Sensitive In Vivo Imaging Modality for the Detection of Dendritic Cell Migration.Molecular imaging and biology · 2022Article
- Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery.Micromachines · 2019Article
- Tracking Neural Progenitor Cell Migration in the Rodent Brain Using Magnetic Resonance Imaging.Frontiers in neuroscience · 2018Review
- Recent progress in the use and tracking of transplanted islets as a personalized treatment for type 1 diabetes.Expert review of precision medicine and drug development · 2017Article
- Tracking and Quantification of Magnetically Labeled Stem Cells using Magnetic Resonance Imaging.Advanced functional materials · 2016Article
- Magnetoencapsulated human islets xenotransplanted into swine: a comparison of different transplantation sites.Xenotransplantation · 2016Article
- Efficient Small Blob Detection Based on Local Convexity, Intensity and Shape Information.IEEE transactions on medical imaging · 2016Article
- Labeling of mesenchymal stem cells for MRI with single-cell sensitivity.International journal of nanomedicine · 2016Article
- Improving detection specificity of iron oxide nanoparticles (IONPs) using the SWIFT sequence with long T(2) suppression.Magnetic resonance imaging · 2014Article
- Molecular magnetic resonance imaging of brain-immune interactions.Frontiers in cellular neuroscience · 2014Review
- Microencapsulated cell tracking.NMR in biomedicine · 2013Review
- Personalized nanomedicine advancements for stem cell tracking.Advanced drug delivery reviews · 2012Review
- Use of Magnetocapsules for In Vivo Visualization and Enhanced Survival of Xenogeneic HepG2 Cell Transplants.Cell medicine · 2012Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Understanding how individual cells behave inside living systems will help enable new diagnostic tools and cellular therapies. Superparamagnetic iron oxide particles can be used to label cells and theranostic capsules for noninvasive tracking using MRI. Contrast changes from superparamagnetic iron oxide are often subtle relative to intrinsic sources of contrast, presenting a detection challenge. Here, we describe a versatile postprocessing method, called Phase map cross-correlation Detection and Quantification (PDQ), that automatically identifies localized deposits of superparamagnetic iron oxide, estimating their volume magnetic susceptibility and magnetic moment. To demonstrate applicability, PDQ was used to detect and characterize superparamagnetic iron oxide-labeled magnetocapsules implanted in porcine liver and suspended in agarose gel. PDQ was also applied to mouse brains infiltrated by MPIO-labeled macrophages following traumatic brain injury; longitudinal, in vivo studies tracked individual MPIO clusters over 3 days, and tracked clusters were corroborated in ex vivo brain scans. Additionally, we applied PDQ to rat hearts infiltrated by MPIO-labeled macrophages in a transplant model of organ rejection. PDQ magnetic measurements were signal-to-noise ratio invariant for images with signal-to-noise ratio > 11. PDQ can be used with conventional gradient-echo pulse sequences, requiring no extra scan time. The method is useful for visualizing biodistribution of cells and theranostic magnetocapsules and for measuring their relative iron content.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.