ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2012
Multi-site bone ultrasound measurements in elderly women with and without previous hip fractures.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 86 citations in OpenAlex.
- Concept of a Radiofrequency Device for Osteopenia/Osteoporosis Screening.Scientific reports · 2020Trial
- Prediction of Fragility Fractures and Mortality in a Cohort of Geriatric Patients.Journal of cachexia, sarcopenia and muscle · 2024Article
- The Biomechanics of Musculoskeletal Tissues during Activities of Daily Living: Dynamic Assessment Using Quantitative Transmission-Mode Ultrasound Techniques.Healthcare (Basel, Switzerland) · 2024Review
- An in vitro demonstration of a passive, acoustic metamaterial as a temperature sensor with mK resolution for implantable applications.Microsystems & nanoengineering · 2024Article
- Pulse-echo ultrasound measurement in osteoporosis screening: a pilot study in older patients.Aging clinical and experimental research · 2023Article
- Clinical Devices for Bone Assessment.Advances in experimental medicine and biology · 2022Review
- Scattering in Cancellous Bone.Advances in experimental medicine and biology · 2022Article
- Pulse-Echo Measurements of Bone Tissues. Techniques and Clinical Results at the Spine and Femur.Advances in experimental medicine and biology · 2022Review
- Covid-19 given opportunity to use ultrasound in the plaster room to continue secondary fracture prevention care: A retrospective Fracture Liaison Service study.International journal of orthopaedic and trauma nursing · 2021Article
- The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bonePhotoacoustics · 2021Article
- Application of a Neural Network Classifier to Radiofrequency-Based Osteopenia/Osteoporosis Screening.IEEE journal of translational engineering in health and medicine · 2021Article
- A Combined Ultrasonic Backscatter Parameter for Bone Status Evaluation in Neonates.Computational and mathematical methods in medicine · 2020Article
- [Diagnostics and treatment of osteoporosis in patients over 65 years old : Current status and future perspectives].Zeitschrift fur Gerontologie und Geriatrie · 2019Review
- Radiofrequency echographic multispectrometry compared with dual X-ray absorptiometry for osteoporosis diagnosis on lumbar spine and femoral neck.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Observational
- Ultrasonic backscatter difference measurements of cancellous bone from the human femur: Relation to bone mineral density and microstructure.The Journal of the Acoustical Society of America · 2018Article
- Pulse-echo ultrasound method for detection of post-menopausal women with osteoporotic BMD.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Characterization of a polymer, open-cell rigid foam that simulates the ultrasonic properties of cancellous bone.The Journal of the Acoustical Society of America · 2018Article
- Cost-effectiveness of pulse-echo ultrasonometry in osteoporosis management.ClinicoEconomics and outcomes research : CEOR · 2018Article
- Effect of gate choice on backscatter difference measurements of cancellous bone.The Journal of the Acoustical Society of America · 2017Article
- Clinical Evaluation of Bone Strength and Fracture Risk.Current osteoporosis reports · 2017Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledAbout 75% of patients suffering from osteoporosis are not diagnosed. This study describes a multi-site bone ultrasound method for osteoporosis diagnostics. In comparison with axial dual energy X-ray absorptiometry (DXA), the ultrasound method showed good diagnostic performance and could discriminate fracture subjects among elderly females.
introductionAxial DXA, the gold standard diagnostic method for osteoporosis, predicts fractures only moderately. At present, no reliable diagnostic methods are available at the primary health care level. Here, a multi-site ultrasound method is proposed for osteoporosis diagnostics.
methodsThirty elderly women were examined using the ultrasound backscatter measurements in proximal femur, proximal radius, proximal and distal tibia in vivo. First, we predicted the areal bone mineral density (BMD) at femoral neck by ultrasound measurements in tibia combined with specific subject characteristics (density index, DI) and, second, we tested the ability of ultrasound backscatter measurements at proximal femur to discriminate between individuals with previously fractured hips from those without fractures. Areal BMD was determined by axial DXA.
resultsCombined ultrasound parameters, cortical thickness at distal and proximal tibia, with age and weight of the subject, provided a significant estimate of BMD(neck) (r = 0.86, p < 0.001, n = 30). When inserted into FRAX (World Health Organization fracture risk assessment tool), the DI indicated the same treatment proposal as the BMD(neck) with 86% sensitivity and 100% specificity. The receiver operating characteristic analyses, with a combination of ultrasound parameters and patient characteristics, discriminated fracture subjects from the controls similarly as the model combining BMD(neck) and patient characteristics.
conclusionsFor the first time, ultrasound backscatter measurements of proximal femur were conducted in vivo. The results indicate that ultrasound parameters, combined with patient characteristics, may provide a means for osteoporosis diagnostics.
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