ArticleEcotoxicology (London, England)2011
Determination of mRNA expression of DMRT93B, vitellogenin, and cuticle 12 in Daphnia magna and their biomarker potential for endocrine disruption.
Article in Ecotoxicology (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Chronic Toxicity of the Synthetic Pyrethroid Tau Fluvalinate to Aquatic Invertebrates: Life History, Oxidative Stress, and Molecular Responses of Daphnia magna.Journal of applied toxicology : JAT · 2026Article
- Epigenetic and Gene Expression Responses ofMolecules (Basel, Switzerland) · 2025Article
- Screening of morphology-related genes based on predator-induced transcriptome sequencing and the functional analysis ofCurrent zoology · 2024Article
- Calmodulin inhibition as a mode of action of antifungal imidazole pharmaceuticals in non-target organisms.Toxicology research · 2020Article
- Detoxification and reproductive system-related gene expression following exposure to Cu(OH)Environmental science and pollution research international · 2020Article
- Phylogenetic analysis and embryonic expression of panarthropod Dmrt genes.Frontiers in zoology · 2019Article
- Article
- Transcriptional profiling of predator-induced phenotypic plasticity in Daphnia pulex.Frontiers in zoology · 2015Article
- Pan-metazoan phylogeny of the DMRT gene family: a framework for functional studies.Development genes and evolution · 2014Article
- Are pharmaceuticals with evolutionary conserved molecular drug targets more potent to cause toxic effects in non-target organisms?PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We explored the use of molecular genetic biomarkers for endocrine disruption in Daphnia magna after the exposure to fenoxycarb (FOC), a model juvenile hormone analog. For this purpose, the mRNA expression patterns of DMRT93B (DMRT, sex determination), cuticle 12 (CUT, molting), and vitellogenin (VTG, embryo development) were determined in D. magna. Furthermore, these results were compared with developmental abnormality and reproduction performance. The fold changes of CUT and VTG mRNA expression showed significant dose-response relationship with FOC exposure. Relative mRNA expressions of DMRT and CUT showed notable changes at as low as 1 ng/l FOC. After chronic exposure FOC significantly delayed the first day of reproduction and decreased the number of young and growth rate even at 10 ng/l FOC. A concentration-dependant trend in reproduction effect was also observed. Developmental abnormality such as poorly developed second antennae and curved or unextended shell spines were observed. These results suggest that the three mRNAs, i.e., DMRT, CUT, and VTG can be used as biomarkers of endocrine disrupting effects in D. magna.
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