ReviewCancer immunology, immunotherapy : CII2011
Cooperativity of adaptive and innate immunity: implications for cancer therapy.
Review in Cancer immunology, immunotherapy : CII, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Article
- Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco flavored e-cigarette exposed mouse lungs.bioRxiv : the preprint server for biology · 2025Article
- Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity.Nature cancer · 2025Article
- Interferon-Gamma Secretion Is Significantly Decreased in Stage III Breast Cancer Patients.International journal of molecular sciences · 2024Article
- Editorial: Lymphocyte functional crosstalk and regulation, volume II.Frontiers in immunology · 2023Article
- Immunoceuticals: Harnessing Their Immunomodulatory Potential to Promote Health and Wellness.Nutrients · 2022Review
- Review
- Development of a novel TLR8 agonist for cancer immunotherapy.Molecular biomedicine · 2020Article
- Critical Neurotransmitters in the Neuroimmune Network.Frontiers in immunology · 2020Review
- A potential role for peripheral natural killer cell activity induced by preoperative chemotherapy in breast cancer patients.Cancer immunology, immunotherapy : CII · 2019Article
- CD8Frontiers in immunology · 2019Article
- Editorial: Lymphocyte Functional Crosstalk and Regulation.Frontiers in immunology · 2019Article
- Expression and function of immune ligand-receptor pairs in NK cells and cancer stem cells: therapeutic implications.Cellular oncology (Dordrecht, Netherlands) · 2018Review
- Manipulation of Innate and Adaptive Immunity through Cancer Vaccines.Journal of immunology research · 2017Review
- Cationic liposomes loaded with a synthetic long peptide and poly(I:C): a defined adjuvanted vaccine for induction of antigen-specific T cell cytotoxicity.The AAPS journal · 2015Article
- Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity.Journal of virology · 2014Article
- Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients.Journal of translational medicine · 2013Article
- Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis.Critical reviews in oncology/hematology · 2013Review
- T and NK cells: two sides of tumor immunoevasion.Journal of translational medicine · 2013Article
- Training the Defense System for Modern-Day Warfare: The Horizons for Immunotherapy and Vaccines for Cancer.Journal of immunodeficiency & disorders · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The dichotomy of immunology into innate and adaptive immunity has created conceptual barriers in appreciating the intrinsic two-way interaction between immune cells. An emerging body of evidence in various models of immune rejection, including cancer, indicates an indispensable regulation of innate effector functions by adaptive immune cells. This bidirectional cooperativity in innate and adaptive immune functions has broad implications for immune responses in general and for regulating the tumor-associated inflammation that overrides the protective antitumor immunity. Mechanistic understanding of this two-way immune cross-talk could provide insights into novel strategies for designing better immunotherapy approaches against cancer and other diseases that normally defy immune control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.