Evidence map›Paper›PMID 2165604›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1990

A distinctive family of embryonic protein-tyrosine kinase receptors.

E B Pasquale

Open access · greenAbstract readComparative Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
19.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 130 citations in OpenAlex.

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  6. Identification of soluble forms of the fibroblast growth factor receptor in blood.Proceedings of the National Academy of Sciences of the United States of America · 1994
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  11. K-sam gene encodes secreted as well as transmembrane receptor tyrosine kinase.Proceedings of the National Academy of Sciences of the United States of America · 1992
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

E B PasqualeDepartment of Biology, University of California, San Diego, La Jolla 92093.
University of California, San Diego · US

Funding

DEVELOPMENTAL BIOLOGY OF EPH-RELATED TYROSINE KINASESR01HD026351 · NICHD · BURNHAM INSTITUTE FOR MEDICAL RESEARCH · PI PASQUALE, ELENA B · 1995 to 1999
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DEVELOPMENTAL BIOLOGY OF PROTEIN TYROSINE KINASESR29HD026351 · NICHD · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI PASQUALE, ELENA B · 1990 to 1994
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NICHD NIH HHS HD26351NIGMS NIH HHS GM15971
6 · The paper itself

Abstract

Two closely related protein-tyrosine kinases with the characteristics of growth factor receptors were identified by screening a chicken embryo cDNA expression library with anti-phosphotyrosine antibodies and were designated Cek2 and Cek3 (chicken embryo kinases 2 and 3). Cek2 and Cek3 are structurally related to Cek1, a chicken basic fibroblast growth factor receptor, and presumably represent receptors for basic fibroblast growth factor-related molecules. The identification of Cek2 and Cek3 establishes the existence of a family of protein-tyrosine kinases that includes Cek1 and that is likely to be implicated in the control of developmental processes. Among protein-tyrosine kinases, this family of receptors, which may include other as yet unknown members, is most closely related to the protooncogene product Ret and the platelet-derived growth factor receptor family.

Indexed as

Multigene FamilyAmino Acid SequenceAnimalsBiological EvolutionChick EmbryoGene LibraryGrowth SubstancesIsoenzymesMolecular Sequence DataProtein-Tyrosine KinasesReceptors, Cell SurfaceRNA, MessengerSequence Homology, Nucleic AcidGrowth SubstancesIsoenzymesProtein-Tyrosine KinasesReceptors, Cell SurfaceRNA, Messenger

Identifiers

PMID2165604
PMCPMC54418
OpenAlexW2028377603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.