ArticleClinics (Sao Paulo, Brazil)2011
Upper airway collapsibility evaluated by a negative expiratory pressure test in severe obstructive sleep apnea.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Trial
- Effect of Muller maneuver on upper airway characteristics and surrounding structures in patients with obstructive sleep apnea: a cone-beam computed tomography study.Scientific reports · 2026Article
- Interpretable Acoustic Features from Wakefulness Tracheal Breathing for OSA Severity Assessment.Journal of clinical medicine · 2026Article
- Obstructive sleep apnea detection during wakefulness: a comprehensive methodological review.Medical & biological engineering & computing · 2024Review
- Relationship between airflow limitation in response to upper airway negative pressure during wakefulness and obstructive sleep apnea severity.Sleep & breathing = Schlaf & Atmung · 2024Article
- Influence of interface and position on upper airway collapsibility assessed by negative expiratory pressure.Sleep & breathing = Schlaf & Atmung · 2017Article
- Upper Airway Collapsibility Assessed by Negative Expiratory Pressure while Awake is Associated with Upper Airway Anatomy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Article
- Expiratory Flow Limitation in Obstructive Sleep Apnea and COPD: A Quantitative Method to Detect Pattern Differences Using the Negative Expiratory Pressure Technique.The open respiratory medicine journal · 2012Article
- Oxidative stress and quality of life in elderly patients with obstructive sleep apnea syndrome: are there differences after six months of Continuous Positive Airway Pressure treatment?Clinics (Sao Paulo, Brazil) · 2012Article
- Observational study on efficacy of negative expiratory pressure test proposed as screening for obstructive sleep apnea syndrome among commercial interstate bus drivers--protocol study.BMC pulmonary medicine · 2011Article
- A negative expiratory pressure test during wakefulness for evaluating the risk of obstructive sleep apnea in patients referred for sleep studies.Clinics (Sao Paulo, Brazil) · 2011Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the usefulness of measuring upper airway collapsibility with a negative expiratory pressure application as a screening test for severe obstructive sleep apnea (OSA).
introductionOSA is a risk factor for cardiovascular disease, and it may have serious consequences. Its recognition may have important implications during the perioperative period. Increased upper airway collapsibility is one of the main determinants of OSA, and its evaluation could be useful for identifying this condition.
methodsSevere OSA and normal subjects (24 in each group) were matched by body mass index and referred to our sleep laboratory. The subjects were enrolled in an overnight sleep study, and a diurnal negative expiratory pressure test was performed. Flow drop (ΔV) and expiratory volume were measured in the first 0.2 s (V(0.2)) of the negative expiratory pressure test.
resultsΔV (%) and V(0.2) (%) values were statistically different between normal and OSA subjects. OSA patients showed a greater decrease in flow than normal subjects. In addition, severely OSA patients exhaled during the first 0.2 s of the negative expiratory pressure application was an average of only 11.2% of the inspired volume compared to 34.2% for the normal subjects. Analysis of the receiver operating characteristics showed that V(0.2) (%) and ΔV (%) could accurately identify severe OSA in subjects with sensitivities of 95.8% and 91.7%, respectively, and specificities of 95.8% and 91.7%, respectively.
conclusionsV(0.2) (%) and ΔV (%) are highly accurate parameters for detecting severe OSA. The pharyngeal collapsibility measurement, which uses negative expiratory pressure during wakefulness, is predictive of collapsibility during sleep.
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