Evidence map›Paper›PMID 21655733›Full record

ArticleCiencia & saude coletiva2011

Cadmium, environmental exposure, and health outcomes.

Soisungwan Satarug, Scott H Garrett, Mary Ann Sens, Donald A Sens

Open access · diamondAbstract read
In one paragraph

Article in Ciencia & saude coletiva, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 383 citations in OpenAlex.

  1. Association of urinary cadmium with risk of diabetes: a meta-analysis.Environmental science and pollution research international · 2017
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. American journal of physiology. Renal physiology · 2022
    Article
  13. Article
  14. Metabolomics reveals the mechanism of Antarctic yeast Rhodotorula mucliaginosa AN5 to cope with cadmium stress.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Article
  15. Article
  16. Environmental Toxins Are a Major Cause of Bone Loss.Integrative medicine (Encinitas, Calif.) · 2021
    Article
  17. Review
  18. Article
  19. Use ofAnimals : an open access journal from MDPI · 2019
    Article
  20. Effects of Mining Activities onAnimals : an open access journal from MDPI · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Soisungwan SatarugDepartment of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA. ssatarug@medicine.nodak.edu
Scott H Garrett
Mary Ann Sens
Donald A Sens
University of North Dakota · US

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Donald A. Sens · 2012 to 2026
$53.0M
WORKSHOPS AND EVALUATIONP20RR016471 · NCRR · UNIVERSITY OF NORTH DAKOTA · PI BOBYLEV, MIKHAIL · 2001 to 2011
$31.7M
Metallothionein Isoform 3 Urinary Marker Bladder CancerR01ES015100 · NIEHS · UNIVERSITY OF NORTH DAKOTA · PI SENS, DONALD A. · 2006 to 2009
$1.5M
NCRR NIH HHS P20 RR016471NIEHS NIH HHS R01 ES015100NIGMS NIH HHS P20 GM103442
6 · The paper itself

Abstract

We provide an update of the issues surrounding health risk assessment of exposure to cadmium in food. Bioavailability of ingested cadmium has been confirmed in studies of persons with elevated dietary exposure, and the findings have been strengthened by the substantial amounts of cadmium accumulated in kidneys, eyes, and other tissues and organs of environmentally exposed individuals. We hypothesized that such accumulation results from the efficient absorption and systemic transport of cadmium, employing multiple transporters that are used for the body's acquisition of calcium, iron, zinc, and manganese. Adverse effects of cadmium on kidney and bone have been observed in environmentally exposed populations at frequencies higher than those predicted from models of exposure. Population data raise concerns about the validity of the current safe intake level that uses the kidney as the sole target in assessing the health risk from ingested cadmium. The data also question the validity of incorporating the default 5% absorption rate in the threshold-type risk assessment model, known as the provisional tolerable weekly intake (PTWI), to derive a safe intake level for cadmium.

Identifiers

PMID21655733
PMCPMC5967636
OpenAlexW2092909009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.