Evidence map›Paper›PMID 21655449›Full record

ArticleCommunicative & integrative biology2011

Systems biomechanics of centrosome positioning: A conserved complexity.

Ivan V Maly

Abstract read
In one paragraph

Article in Communicative & integrative biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Ivan V MalyDepartment of Computational and Systems Biology; University of Pittsburgh School of Medicine; Pittsburgh, PA USA.

Funding

Quantitative Study of T-cell PolarizationR01GM078332 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALY, IVAN V · 2006 to 2010
$1.4M
NIGMS NIH HHS R01 GM078332
6 · The paper itself

Abstract

Positioning of centrosomes within cells determines the directionality of cell division, as well as directionality of cellular activities in the interphase. This brief review focuses on similarities (and differences) of centrosome positioning during early divisions in the Caenorhabditis embryo and during the interaction of T lymphocytes with other cells in the course of immune response. In the study of the two phenomena, a synergy of experimentation and numerical mechanical analysis has recently been achieved. The picture that emerges from these studies is one in which simple physical forces under the constraints of the basic cell structure lead to complex, "life-like" mechanical behavior. This behavior includes instability of equilibria, irreversibility of structural transitions and multidimensional, multiperiodic oscillations. This new picture of cell mechanics may form an interesting paradigm for future research.

Indexed as

antigen-presenting cellCaenorhabditis eleganslymphocytemicrotubule-organizing centermodelingpolaritypolarizationspindleT cell

Identifiers

PMID21655449
PMCPMC3104588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.