ArticlePloS one2011
A compendium of canine normal tissue gene expression.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Transcriptional assessment by microarray analysis and large-scale meta-analysis of the metabolic capacity of cardiac and skeletal muscle tissues to cope with reduced nutrient availability in Gilthead Sea Bream (Sparus aurata L.).Marine biotechnology (New York, N.Y.) · 2014Pooled it
- Preclinical species gene expression database: Development and meta-analysis.Frontiers in genetics · 2022Article
- Man's best friend in life and death: scientific perspectives and challenges of dog brain banking.GeroScience · 2021Review
- Breed Differences in Dog Cognition Associated with Brain-Expressed Genes and Neurological Functions.Integrative and comparative biology · 2020Article
- Coronavirus genomes carry the signatures of their habitats.PloS one · 2020Article
- Highly heritable and functionally relevant breed differences in dog behaviour.Proceedings. Biological sciences · 2019Article
- Ancient RNA from Late Pleistocene permafrost and historical canids shows tissue-specific transcriptome survival.PLoS biology · 2019Article
- Naturally Occurring Canine Melanoma as a Predictive Comparative Oncology Model for Human Mucosal and Other Triple Wild-Type Melanomas.International journal of molecular sciences · 2018Review
- Detect tissue heterogeneity in gene expression data with BioQC.BMC genomics · 2017Article
- Cellular Microbiology of Mycoplasma canis.Infection and immunity · 2016Article
- Gene Expression Profiling Reveals Functional Specialization along the Intestinal Tract of a Carnivorous Teleostean Fish (Dicentrarchus labrax).Frontiers in physiology · 2016Article
- Reference genes for reverse transcription quantitative PCR in canine brain tissue.BMC research notes · 2015Article
- A Multi-Breed Genome-Wide Association Analysis for Canine Hypothyroidism Identifies a Shared Major Risk Locus on CFA12.PloS one · 2015Article
- De Novo Assembly and Transcriptome Characterization of Canine Retina Using High-Throughput Sequencing.Genetics research international · 2015Article
- Exploiting cancer genomics in pet animals to gain advantage for personalized medicine decisions.Journal of applied genetics · 2014Article
- Transcriptional changes in canine distemper virus-induced demyelinating leukoencephalitis favor a biphasic mode of demyelination.PloS one · 2014Article
- Article
- Analysis of the canine brain transcriptome with an emphasis on the hypothalamus and cerebral cortex.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs.Clinical orthopaedics and related research · 2013Article
- Franklin H. Epstein Lecture. Both ends of the leash--the human links to good dogs with bad genes.The New England journal of medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOur understanding of disease is increasingly informed by changes in gene expression between normal and abnormal tissues. The release of the canine genome sequence in 2005 provided an opportunity to better understand human health and disease using the dog as clinically relevant model. Accordingly, we now present the first genome-wide, canine normal tissue gene expression compendium with corresponding human cross-species analysis. METHODOLOGY/PRINCIPAL
findingsThe Affymetrix platform was utilized to catalogue gene expression signatures of 10 normal canine tissues including: liver, kidney, heart, lung, cerebrum, lymph node, spleen, jejunum, pancreas and skeletal muscle. The quality of the database was assessed in several ways. Organ defining gene sets were identified for each tissue and functional enrichment analysis revealed themes consistent with known physio-anatomic functions for each organ. In addition, a comparison of orthologous gene expression between matched canine and human normal tissues uncovered remarkable similarity. To demonstrate the utility of this dataset, novel canine gene annotations were established based on comparative analysis of dog and human tissue selective gene expression and manual curation of canine probeset mapping. Public access, using infrastructure identical to that currently in use for human normal tissues, has been established and allows for additional comparisons across species. CONCLUSIONS/SIGNIFICANCE: These data advance our understanding of the canine genome through a comprehensive analysis of gene expression in a diverse set of tissues, contributing to improved functional annotation that has been lacking. Importantly, it will be used to inform future studies of disease in the dog as a model for human translational research and provides a novel resource to the community at large.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.