ArticlePloS one2011
Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Recombination between fragile regions associated with chromosomal rearrangements in glioblastoma can be mediated by RAGs.iScience · 2025Article
- Current insights into the expression and functions of tumor-derived immunoglobulins.Cell death discovery · 2021Review
- 'One DB to rule them all'-the RING: a Regulatory INteraction Graph combining TFs, genes/proteins, SNPs, diseases and drugs.Database : the journal of biological databases and curation · 2019Article
- Article
- Corrected and Republished from: BCL11A Is a Critical Component of a Transcriptional Network That Activates RAG Expression and V(D)J Recombination.Molecular and cellular biology · 2018Article
- iRAGu: A Novel Inducible and Reversible Mouse Model for Ubiquitous Recombinase Activity.Frontiers in immunology · 2017Article
- Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment.International journal of molecular sciences · 2016Review
- Ikaros, Helios, and Aiolos protein levels increase in human thymocytes after β selection.Immunologic research · 2016Article
- Foxp1/2/4 regulate endochondral ossification as a suppresser complex.Developmental biology · 2015Article
- Chronic lymphocytic leukaemia: could immunological tolerance mechanisms be the origin of lymphoid neoplasms?Immunology · 2014Review
- Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer.Epigenetics · 2014Article
- Activation of the Ig Iα1 promoter by the transcription factor Ets-1 triggers Ig Iα1-Cα1 germline transcription in epithelial cancer cells.Cellular & molecular immunology · 2014Article
- Article
- The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination.Molecular and cellular biology · 2013Article
- Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609.Genes and immunity · 2013Article
- Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling.Molecular systems biology · 2013Article
- NotI microarrays: novel epigenetic markers for early detection and prognosis of high grade serous ovarian cancer.International journal of molecular sciences · 2012Article
- Bidirectional activity of the NWC promoter is responsible for RAG-2 transcription in non-lymphoid cells.PloS one · 2012Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has long been accepted that immunoglobulins (Igs) were produced by B lymphoid cells only. Recently Igs have been found to be expressed in various human cancer cells and promote tumor growth. Recombination activating gene 1 (RAG1) and RAG2, which are essential enzymes for initiating variable-diversity-joining segment recombination, have also been found to be expressed in cancer cells. However, the mechanism of RAG activation in these cancer cells has not been elucidated. Here, we investigated the regulatory mechanism of RAG expression in four human cancer cell lines by analyzing transcription factors that induce RAG activation in B cells. By RT-PCR, Western blot and immunofluorescence, we found that transcription factors E2A, FOXO1 and FOXP1 were expressed and localized to the nuclei of these cancer cells. Over-expression of E2A, FOXO1 or Foxp1 increased RAG expression, while RNA interference of E2A, FOXO1 or FOXP1 decreased RAG expression in the cancer cells. Chromatin immunoprecipitation experiments showed acetylation of RAG enhancer (Erag) and E2A, FOXO1 or FOXP1 were bound to Erag in vivo. These results indicate that in these cancer cells the transcription factors E2A, FOXO1 and FOXP1 regulate RAG expression, which initiates Ig gene rearrangement much in the way similar to B lymphocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.