ArticlePloS one2011
Complete genome sequence of Treponema paraluiscuniculi, strain Cuniculi A: the loss of infectivity to humans is associated with genome decay.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 80 citations in OpenAlex.
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- PoMeLo: a systematic computational approach to predicting metabolic loss in pathogen genomes.BMC bioinformatics · 2024Article
- High prevalence and genetic diversity ofMicrobiology spectrum · 2024Article
- The hare syphilis agent is related to, but distinct from, the treponeme causing rabbit syphilis.PloS one · 2024Article
- Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms.PLoS pathogens · 2021Article
- Parameters Affecting ContinuousmBio · 2021Article
- Penicillin Treatment Failure in Rabbit Syphilis Due to the Persistence of Treponemes (Frontiers in veterinary science · 2021Article
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- Identification and Functional Assessment of the First Placental Adhesin ofFrontiers in microbiology · 2020Article
- First report of hare treponematosis seroprevalence of European brown hares (Lepus europaeus) in the Czech Republic: seroprevalence negatively correlates with altitude of sampling areas.BMC veterinary research · 2019Article
- Comparative genomics of the transportome of Ten Treponema species.Microbial pathogenesis · 2019Article
- Identification of positively selected genes in human pathogenic treponemes: Syphilis-, yaws-, and bejel-causing strains differ in sets of genes showing adaptive evolution.PLoS neglected tropical diseases · 2019Article
- Profile of the tprK gene in primary syphilis patients based on next-generation sequencing.PLoS neglected tropical diseases · 2019Article
- Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Indonesia: Modular structure of several treponemal genes.PLoS neglected tropical diseases · 2018Article
- Functional insights from proteome-wide structural modeling of Treponema pallidum subspecies pallidum, the causative agent of syphilis.BMC structural biology · 2018Article
- Gene target selection for loop-mediated isothermal amplification for rapid discrimination of Treponema pallidum subspecies.PLoS neglected tropical diseases · 2018Article
- Diagnostics for Yaws Eradication: Insights From Direct Next-Generation Sequencing of Cutaneous Strains of Treponema pallidum.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea.PLoS neglected tropical diseases · 2017Article
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Treponema paraluiscuniculi is the causative agent of rabbit venereal spirochetosis. It is not infectious to humans, although its genome structure is very closely related to other pathogenic Treponema species including Treponema pallidum subspecies pallidum, the etiological agent of syphilis. In this study, the genome sequence of Treponema paraluiscuniculi, strain Cuniculi A, was determined by a combination of several high-throughput sequencing strategies. Whereas the overall size (1,133,390 bp), arrangement, and gene content of the Cuniculi A genome closely resembled those of the T. pallidum genome, the T. paraluiscuniculi genome contained a markedly higher number of pseudogenes and gene fragments (51). In addition to pseudogenes, 33 divergent genes were also found in the T. paraluiscuniculi genome. A set of 32 (out of 84) affected genes encoded proteins of known or predicted function in the Nichols genome. These proteins included virulence factors, gene regulators and components of DNA repair and recombination. The majority (52 or 61.9%) of the Cuniculi A pseudogenes and divergent genes were of unknown function. Our results indicate that T. paraluiscuniculi has evolved from a T. pallidum-like ancestor and adapted to a specialized host-associated niche (rabbits) during loss of infectivity to humans. The genes that are inactivated or altered in T. paraluiscuniculi are candidates for virulence factors important in the infectivity and pathogenesis of T. pallidum subspecies.
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