ArticlePloS one2011
Matrix recruitment and calcium sequestration for spatial specific otoconia development.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Association of benign paroxysmal positional vertigo with vitamin D deficiency: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Pooled it
- Serum Otoconin-90 and Otolin-1 Concentrations in Benign Paroxysmal Positional Vertigo.Biomolecules · 2024Article
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- Injectable thermosensitive chitosan/gelatin hydrogel for dental pulp stem cells proliferation and differentiation.BioImpacts : BI · 2023Article
- Association of Serum Calcium and Vitamin D with Benign Paroxysmal Positional Vertigo.International archives of otorhinolaryngology · 2022Article
- Vitamin D Insufficiency/Deficiency in Patients with Recurrent Benign Paroxysmal Positional Vertigo.The journal of international advanced otology · 2022Article
- Low 25-Hydroxyvitamin D Levels Are Associated With Residual Dizziness After Successful Treatment of Benign Paroxysmal Positional Vertigo.Frontiers in neurology · 2022Article
- Development and evolution of the vestibular apparatuses of the inner ear.Journal of anatomy · 2021Review
- Otoconia Structure After Short- and Long-Duration Exposure to Altered Gravity.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Natural Mutations Affect Structure and Function of gC1q Domain of Otolin-1.International journal of molecular sciences · 2021Article
- Relation between vitamin D deficiency and benign paroxysmal positional vertigo.Scientific reports · 2021Article
- Molecular Mediators of Estrogen Reduction-induced Otolith Shedding.Current medical science · 2021Article
- Molecular mechanism of calcium induced trimerization of C1q-like domain of otolin-1 from human and zebrafish.Scientific reports · 2021Article
- Whole-Genome Sequencing and Genome-Wide Studies of Spiny Head Croaker (Frontiers in genetics · 2021Article
- Functional cooperation between two otoconial proteins Oc90 and Nox3.Journal of vestibular research : equilibrium & orientation · 2021Article
- Otoliths-composed gelatin/sodium alginate scaffolds for bone regeneration.Drug delivery and translational research · 2020Article
- Otopetrin-2 Immunolocalization in the Human Macula Utricle.The Annals of otology, rhinology, and laryngology · 2019Article
- Zebrafish otolith biomineralization requires polyketide synthase.Mechanisms of development · 2019Article
- Mechanism Underlying the Effects of Estrogen Deficiency on Otoconia.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- A Relationship Between Blood Levels of Otolin-1 and Vitamin D.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Otoconia are bio-crystals anchored to the macular sensory epithelium of the utricle and saccule in the inner ear for motion sensing and bodily balance. Otoconia dislocation, degeneration and ectopic calcification can have detrimental effects on balance and vertigo/dizziness, yet the mechanism underlying otoconia formation is not fully understood. In this study, we show that selected matrix components are recruited to form the crystal matrix and sequester Ca(2+) for spatial specific formation of otoconia. Specifically, otoconin-90 (Oc90) binds otolin through both domains (TH and C1q) of otolin, but full-length otolin shows the strongest interaction. These proteins have much higher expression levels in the utricle and saccule than other inner ear epithelial tissues in mice. In vivo, the presence of Oc90 in wildtype (wt) mice leads to an enrichment of Ca(2+) in the luminal matrices of the utricle and saccule, whereas absence of Oc90 in the null mice leads to drastically reduced matrix-Ca(2+). In vitro, either Oc90 or otolin can increase the propensity of extracellular matrix to calcify in cell culture, and co-expression has a synergistic effect on calcification. Molecular modeling and sequence analysis predict structural features that may underlie the interaction and Ca(2+)-sequestering ability of these proteins. Together, the data provide a mechanism for the otoconial matrix assembly and the role of this matrix in accumulating micro-environmental Ca(2+) for efficient CaCO(3) crystallization, thus uncover a critical process governing spatial specific otoconia formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.