ArticlePloS one2011
Increased insensible water loss contributes to aging related dehydration.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Lipidomic fingerprints reveal sex-, age-, and disease-dependent differences in the TgF344-AD transgenic rats.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Hydration Strategies in Older Adults.Nutrients · 2025Review
- The Emerging Role of Water Loss in Dog Aging.Cells · 2025Review
- Wireless, soft electronics for rapid, multisensor measurements of hydration levels in healthy and diseased skin.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Comprehensive Analysis of Heat and Water Exchanges in the Human Lungs.Frontiers in physiology · 2021Article
- Age-Dependent Decline in Salinity Tolerance in a Euryhaline Fish.Frontiers in aging · 2021Article
- Age-Related Changes in the Thermoregulatory Properties in Bank Voles From a Selection Experiment.Frontiers in physiology · 2020Article
- Effects of Drugs and Excipients on Hydration Status.Nutrients · 2019Review
- Article
- Sex differences in amino acids lost via sweating could lead to differential susceptibilities to disturbances in nitrogen balance and collagen turnover.Amino acids · 2017Article
- Resilience in Aging Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Effect of Ventilated Caging on Water Intake and Loss in 4 Strains of Laboratory Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- Secretion of von Willebrand factor by endothelial cells links sodium to hypercoagulability and thrombosis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Dehydration with aging is attributed to decreased urine concentrating ability and thirst. We further investigated by comparing urine concentration and water balance in 3, 18 and 27 month old mice, consuming equal amounts of water. During water restriction, 3 month old mice concentrate their urine sufficiently to maintain water balance (stable weight). 18 month old mice concentrate their urine as well, but still lose weight (negative water balance). 27 month old mice do not concentrate their urine as well and lose even more weight than the 18 month old mice, indicating a larger negative water balance. Negative water balance in older mice is accompanied by increased vasopressin excretion, providing further evidence of dehydration. All 3 groups maintain water balance while consuming only the water in gel food containing 56% water. However, both older groups excrete a smaller volume of urine of higher osmolality, indicating greater extra urinary water loss. Since their feces also contain less water, the excess water lost by the older mice apparently is through other routes, presumably insensible loss through the respiratory tract and skin. The greater insensible water loss occurs at an earlier age (18 months) than decreased urine concentrating ability (27 months). We propose that insensible water loss through skin and respiration increases with age, making a major contribution to aging related dehydration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.