ArticleInternational journal of environmental research and public health2011
Cross-sectional analysis of the utility of pulmonary function tests in predicting emphysema in ever-smokers.
Article in International journal of environmental research and public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Morphological measurements in computed tomography correlate with airflow obstruction in chronic obstructive pulmonary disease: systematic review and meta-analysis.European radiology · 2012Pooled it
- Contribution of adaptive immunity to human COPD and experimental models of emphysema.Physiological reviews · 2023Review
- Quantitative CT parameters correlate with lung function in chronic obstructive pulmonary disease: A systematic review and meta-analysis.Frontiers in surgery · 2022Review
- Phenotyping COPD Patients with Emphysema Distribution Using Quantitative CT Measurement; More Severe Airway Involvement in Lower Dominant Emphysema.International journal of chronic obstructive pulmonary disease · 2022Article
- Lung tissue microbial profile in lung cancer is distinct from emphysema.American journal of cancer research · 2018Article
- Clinical characteristics of chronic bronchitic, emphysematous and ACOS phenotypes in COPD patients with frequent exacerbations.International journal of chronic obstructive pulmonary disease · 2017Article
- Cigarette Smoke and DNA Cleavage Promote Lung Inflammation and Emphysema.Transactions of the American Clinical and Climatological Association · 2017Review
- CT-derived Biomechanical Metrics Improve Agreement Between Spirometry and Emphysema.Academic radiology · 2016Article
- Clinical and Immunological Factors in Emphysema Progression. Five-Year Prospective Longitudinal Exacerbation Study of Chronic Obstructive Pulmonary Disease (LES-COPD).American journal of respiratory and critical care medicine · 2015Article
- Article
- Activation of C3a receptor is required in cigarette smoke-mediated emphysema.Mucosal immunology · 2015Article
- The Effects of Bikram Yoga on Health: Critical Review and Clinical Trial Recommendations.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Review
- Agonistic induction of PPARγ reverses cigarette smoke-induced emphysema.The Journal of clinical investigation · 2014Article
- Disproportionate contribution of right middle lobe to emphysema and gas trapping on computed tomography.PloS one · 2014Observational
- Autoimmunity in chronic obstructive pulmonary disease: clinical and experimental evidence.Expert review of clinical immunology · 2012Review
- Autoreactive T Cells in Human Smokers is Predictive of Clinical Outcome.Frontiers in immunology · 2012Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Emphysema is largely an under-diagnosed medical condition that can exist in smokers in the absence of airway obstruction. We aimed to determine the sensitivity and specificity of pulmonary function tests (PFTs) in assessing emphysema using quantitative CT scans as the reference standard. We enrolled 224 ever-smokers (current or former) over the age of 40. CT of thorax was used to quantify the low attenuation area (% emphysema), and to measure the standardized airway wall thickness. PFTs were used individually and in combination to predict their ability to discriminate radiographic emphysema. Significant emphysema (>7%) was detected in 122 (54%) subjects. Twenty six (21%) emphysema subjects had no evidence of airflow obstruction (FEV(1)/FVC ratio <70%), while all subjects with >23% emphysema showed airflow obstruction. The sensitivity and specificity of spirometry for detecting radiographic emphysema were 79% and 75%, respectively. Standardized airway wall thickness was increased in subjects with airflow obstruction, but did not correlate with emphysema severity. In this cohort of lifetime ever-smokers, PFTs alone were inadequate for diagnosing emphysema. Airway wall thickness quantified by CT morphometry was associated with airflow limitation, but not with emphysema indicating that the heterogeneous nature of lung disease in smokers may represent distinct phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.