ArticlePLoS genetics2011
Distinct functional constraints partition sequence conservation in a cis-regulatory element.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Lineage-resolved analysis of embryonic gene expression evolution inScience (New York, N.Y.) · 2025Article
- Genome-wide oscillations in G + C density and sequence conservation.Genome research · 2021Article
- Evolution of New cis-Regulatory Motifs Required for Cell-Specific Gene Expression in Caenorhabditis.PLoS genetics · 2016Article
- Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks.Current biology : CB · 2016Article
- Conserved Cis-Regulatory Modules Control Robustness in Msx1 Expression at Single-Cell Resolution.Genome biology and evolution · 2015Article
- Natural variation of the expression pattern of the segmentation gene even-skipped in melanogaster.Developmental biology · 2015Article
- Phylum-Level Conservation of Regulatory Information in Nematodes despite Extensive Non-coding Sequence Divergence.PLoS genetics · 2015Article
- Evolutionary meandering of intermolecular interactions along the drift barrier.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Pervasive divergence of transcriptional gene regulation in Caenorhabditis nematodes.PLoS genetics · 2014Article
- Comparative RNAi screens in C. elegans and C. briggsae reveal the impact of developmental system drift on gene function.PLoS genetics · 2014Article
- Multidimensional adaptive evolution of a feed-forward network and the illusion of compensation.Evolution; international journal of organic evolution · 2013Article
- Coevolution within and between regulatory loci can preserve promoter function despite evolutionary rate acceleration.PLoS genetics · 2012Article
- Comparative studies of gene expression and the evolution of gene regulation.Nature reviews. Genetics · 2012Review
- Shadow enhancers: frequently asked questions about distributed cis-regulatory information and enhancer redundancy.BioEssays : news and reviews in molecular, cellular and developmental biology · 2012Article
- Tempo and mode in evolution of transcriptional regulation.PLoS genetics · 2012Review
- Macro-level modeling of the response of C. elegans reproduction to chronic heat stress.PLoS computational biology · 2012Article
- Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness.PLoS genetics · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Different functional constraints contribute to different evolutionary rates across genomes. To understand why some sequences evolve faster than others in a single cis-regulatory locus, we investigated function and evolutionary dynamics of the promoter of the Caenorhabditis elegans unc-47 gene. We found that this promoter consists of two distinct domains. The proximal promoter is conserved and is largely sufficient to direct appropriate spatial expression. The distal promoter displays little if any conservation between several closely related nematodes. Despite this divergence, sequences from all species confer robustness of expression, arguing that this function does not require substantial sequence conservation. We showed that even unrelated sequences have the ability to promote robust expression. A prominent feature shared by all of these robustness-promoting sequences is an AT-enriched nucleotide composition consistent with nucleosome depletion. Because general sequence composition can be maintained despite sequence turnover, our results explain how different functional constraints can lead to vastly disparate rates of sequence divergence within a promoter.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.