ArticleNeuropsychiatric disease and treatment2011
Nondrug-related aspect of treating Ekbom disease, formerly known as restless legs syndrome.
Article in Neuropsychiatric disease and treatment, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Clinical Efficacy and Safety of Massage for the Treatment of Restless Leg Syndrome in Hemodialysis Patients: A Meta-Analysis of 5 Randomized Controlled Trials.Frontiers in psychiatry · 2022Pooled it
- Acupressure reduces the severity of restless legs syndrome in hemodialysis patients: A cluster-randomized crossover pilot study.Biomedical journal · 2022Trial
- Development of a Stepped-Care Pathway for Managing Willis-Ekbom Disease/Restless Legs Syndrome During Pregnancy: A Best Evidence Synthesis.Nature and science of sleep · 2026Article
- Restless Legs Syndrome and the Use of Antipsychotic Medication: An Updated Literature Review.Cureus · 2022Review
- Diagnostic and Treatment Considerations in Restless Legs Syndrome Complicated by Diabetic Neuropathy.Current diabetes reports · 2021Review
- Aromatherapy Massage vs. Foot Reflexology on the Severity of Restless Legs Syndrome in Female Patients Undergoing Hemodialysis.Geriatrics (Basel, Switzerland) · 2021Article
- Effectiveness and safety of massage in the treatment of restless legs syndrome: A protocol for systematic review and meta analysis.Medicine · 2020Article
- Restless Leg Syndrome in Peripheral Artery Disease: Prevalence among Patients with Claudication and Benefits from Low-Intensity Exercise.Journal of clinical medicine · 2019Article
- Restless legs syndrome and pregnancy: prevalence, possible pathophysiological mechanisms and treatment.Acta neurologica Scandinavica · 2016Review
- Lifestyle Factors and Risk of Restless Legs Syndrome: Prospective Cohort Study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Article
- The Effect of Massage With Lavender Oil on Restless Leg Syndrome in Hemodialysis Patients: A Randomized Controlled Trial.Nursing and midwifery studies · 2015Article
- Sleep disorders in chronic obstructive pulmonary disease: etiology, impact, and management.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Review
- Medical devices for restless legs syndrome - clinical utility of the Relaxis pad.Therapeutics and clinical risk management · 2015Review
- What patients do to counteract the symptoms of Willis-Ekbom disease (RLS/WED): Effect of gender and severity of illness.Annals of Indian Academy of Neurology · 2014Article
- Physical activity and self-reported symptoms of insomnia, restless legs syndrome, and depression: the comprehensive dialysis study.Hemodialysis international. International Symposium on Home Hemodialysis · 2013Article
- Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment.Sleep & breathing = Schlaf & Atmung · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ekbom disease (EKD), formerly known as restless legs syndrome (RLS) has affected and bothered many people over the centuries. It is one of the most prevalent neurological disorders in Europe and North-America, affecting about 10% of the population. The main characteristics are the strong urge to move, accompanied or caused by uncomfortable, sometimes even distressing, paresthesia of the legs, described as a "creeping, tugging, pulling" feeling. The symptoms often become worse as the day progresses, leading to sleep disturbances or sleep deprivation, which leads to decreased alertness and daytime functions. Numerous studies have been conducted assessing the efficacy of dopaminergic drugs, opioids, and other pharmacologic agents in alleviating EKD symptoms. However, there is also a growing body of evidence demonstrating the effectiveness of nonpharmacologic treatments including life style changes, physical activity programs, pneumatic compression, massage, near-infrared light therapy, and complementary therapies. The working mechanisms behind these alternatives are diverse. Some increase blood flow to the legs, therefore reducing tissue hypoxia; some introduce an afferent counter stimulus to the cortex and with that "close the gate" for aberrant nerve stimulations; some increase dopamine and nitric oxide and therefore augment bio-available neurotransmitters; and some generate endorphins producing an analgesic effect. The advantages of these treatments compared with pharmacologic agents include less or no side effects, no danger of augmentation, and less cost.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.