Evidence map›Paper›PMID 21654717›Full record

ReviewNature reviews. Neurology2011

Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis.

Andrew L Mammen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Observational
  8. Article
  9. When should a neonatologist consult a rheumatologist?European journal of pediatrics · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Immune-mediated necrotizing myopathy: Report of two cases.World journal of clinical cases · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Andrew L MammenDepartment of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins Myositis Center, Mason F. Lord Building Center Tower, Suite 4500, Baltimore, MD 21224, USA. USA. amammen@jhmi.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The different autoimmune myopathies-for example, dermatomyositis, polymyositis, and immune-mediated necrotizing myopathies (IMNM)-have unique muscle biopsy findings, but they also share specific clinical features, such as proximal muscle weakness and elevated serum levels of muscle enzymes. Furthermore, around 60% of patients with autoimmune myopathy have been shown to have a myositis-specific autoantibody, each of which is associated with a distinct clinical phenotype. The typical clinical presentations of the autoimmune myopathies are reviewed here, and the different myositis-specific autoantibodies, including the anti-synthetase antibodies, dermatomyositis-associated antibodies, and IMNM-associated antibodies, are discussed in detail. This Review also focuses on a newly recognized form of IMNM that is associated with statin use and the production of autoantibodies that recognize 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the pharmacological target of statins. The contribution of interferon signaling to the development of dermatomyositis and the potential link between malignancies and the initiation of autoimmune myopathies are also assessed.

Indexed as

AutoantibodiesAutoimmune DiseasesBiopsyDermatomyositisElectromyographyHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLigasesMagnetic Resonance ImagingMuscle, SkeletalMuscle WeaknessMuscular DiseasesMyositisNeoplasmsPhenotypeRiskAutoantibodiesHydroxymethylglutaryl-CoA Reductase InhibitorsLigases

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.