ArticleJournal of visualized experiments : JoVE2011
Trichuris muris infection: a model of type 2 immunity and inflammation in the gut.
Article in Journal of visualized experiments : JoVE, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Chlamydia muridarum Infection Impacts Murine Models of Intestinal Inflammation and Cancer.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- A Trefoil factor 3-Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection.Mucosal immunology · 2024Article
- Trichinella spiralis -induced immunomodulation signatures on gut microbiota and metabolic pathways in mice.PLoS pathogens · 2024Article
- Near-infrared spectroscopy and machine learning algorithms for rapid and non-invasive detection of Trichuris.PLoS neglected tropical diseases · 2023Article
- Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching.PLoS pathogens · 2023Article
- Basophil responses in susceptible AKR mice upon infection with the intestinal helminth parasite Trichuris muris.Parasite immunology · 2023Article
- Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching.bioRxiv : the preprint server for biology · 2023Article
- Clostridia isolated from helminth-colonized humans promote the life cycle of Trichuris species.Cell reports · 2022Article
- Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes.Cell host & microbe · 2022Article
- Tissue-specific immunity in helminth infections.Mucosal immunology · 2022Review
- Review
- Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.Immunity · 2021Article
- Early induction of C/EBPβ expression as a potential marker of steroid responsive colitis.Scientific reports · 2019Article
- The effects of living in an outdoor enclosure on hippocampal plasticity and anxiety-like behavior in response to nematode infection.Hippocampus · 2019Article
- Rapid environmental effects on gut nematode susceptibility in rewilded mice.PLoS biology · 2018Article
- Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.PLoS pathogens · 2016Article
- Possible mechanisms of host resistance to Haemonchus contortus infection in sheep breeds native to the Canary Islands.Scientific reports · 2016Article
- Low-Dose Intestinal Trichuris muris Infection Alters the Lung Immune Microenvironment and Can Suppress Allergic Airway Inflammation.Infection and immunity · 2016Article
- Animal models to study acute and chronic intestinal inflammation in mammals.Gut pathogens · 2015Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Trichuris muris is a natural pathogen of mice and is biologically and antigenically similar to species of Trichuris that infect humans and livestock. Infective eggs are given by oral gavage, hatch in the distal small intestine, invade the intestinal epithelial cells (IECs) that line the crypts of the cecum and proximal colon and upon maturation the worms release eggs into the environment. This model is a powerful tool to examine factors that control CD4(+) T helper (Th) cell activation as well as changes in the intestinal epithelium. The immune response that occurs in resistant inbred strains, such as C57BL/6 and BALB/c, is characterized by Th2 polarized cytokines (IL-4, IL-5 and IL-13) and expulsion of worms while Th1-associated cytokines (IL-12, IL-18, IFN-γ) promote chronic infections in genetically susceptible AKR/J mice. Th2 cytokines promote physiological changes in the intestinal microenvironment including rapid turnover of IECs, goblet cell differentiation, recruitment and changes in epithelial permeability and smooth muscle contraction, all of which have been implicated in worm expulsion. Here we detail a protocol for propagating Trichuris muris eggs which can be used in subsequent experiments. We also provide a sample experimental harvest with suggestions for post-infection analysis. Overall, this protocol will provide researchers with the basic tools to perform a Trichuris muris mouse infection model which can be used to address questions pertaining to Th proclivity in the gastrointestinal tract as well as immune effector functions of IECs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.