Evidence map›Paper›PMID 21654422›Full record

ArticleJournal of occupational and environmental medicine2011

Feasibility of biomarker studies for engineered nanoparticles: what can be learned from air pollution research.

Ning Li, Andre E Nel

Abstract read
In one paragraph

Article in Journal of occupational and environmental medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Opportunities and challenges of nanotechnology in the green economy.Environmental health : a global access science source · 2014
    Review
  2. Article
  3. Occupational safety and health criteria for responsible development of nanotechnology.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2014
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ning LiDivision of NanoMedicine, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. nli@ucla.edu
Andre E Nel

Funding

Xenobiotics, Oxidative Stress and Allergic InflammationU19AI070453 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOO, JOSEPH A · 2006 to 2010
$6.7M
Scientific Core: Acquisition, Synthesis, and Characterization of NanomaterialsU19ES019528 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NEL, ANDRE ELIAS · 2010 to 2014
$5.5M
Predictive Toxicological Paradigms to Establish Inhalation Toxicology ModelsRC2ES018766 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NEL, ANDRE ELIAS · 2009 to 2010
$1.1M
NIAID NIH HHS U19 AI-070453NIAID NIH HHS U19 AI070453NIEHS NIH HHS RC2 ES018766NIEHS NIH HHS RC2 ES-018766-01NIEHS NIH HHS U19ES019528
6 · The paper itself

Abstract

objectiveOccupational exposure to engineered nanoparticles (NP) may pose health risks to the workers. This article is to discuss the feasibility of identifying biomarkers that are associated with NP exposure.

methodsScientific literature on the adverse health effects of ambient ultrafine particles (UFP) and NP was reviewed to discuss the feasibility of conducting biomarker studies to identify NP-induced early biological changes.

resultsVarious approaches for biomarker studies have been identified, including potential injury pathways that need to be considered and the methodologies that may be used for such studies.

conclusionsAlthough NP may have novel mechanisms of injury, much can be learned from our experience in studying UFP. Oxidative stress-related pathways can be an important consideration for identifying NP-associated biomarkers, and one of the most effective approaches for such studies may be proteome profiling. CLINICAL SIGNIFICANCE: Biomarker studies will provide valuable information to identify early biological events associated with the adverse health effects of engineered nanomaterials before the manifestation of clinical outcomes. This is particularly important for the health surveillance of workers who may be at higher risk due to their occupational settings.

Indexed as

BiomarkersNanotechnologyOccupational ExposureCells, CulturedHumansInflammationNanostructuresOxidative StressProteomicsReactive Oxygen SpeciesBiomarkersReactive Oxygen Species

Identifiers

PMID21654422
PMCPMC3163229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.