Trial reportDiseases of the colon and rectum2011
Inverse relationship between moderate alcohol intake and rectal cancer: analysis of the North Carolina Colon Cancer Study.
Trial report in Diseases of the colon and rectum, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Diet as a Risk Factor for Early-Onset Colorectal Adenoma and Carcinoma: A Systematic Review.Frontiers in nutrition · 2022Pooled it
- Quantitative risk of positive family history in developing colorectal cancer: A meta-analysis.World journal of gastroenterology · 2019Pooled it
- Lower Relative Contribution of Positive Family History to Colorectal Cancer Risk with Increasing Age: A Systematic Review and Meta-Analysis of 9.28 Million Individuals.The American journal of gastroenterology · 2018Pooled it
- Mediterranean Alcohol-Drinking Pattern and Alcohol-Related Cancer Incidence in the "Seguimiento Universidad de Navarra" (SUN) Cohort.Medical sciences (Basel, Switzerland) · 2025Article
- Ferulic Acid Induces Autophagy and Apoptosis in Colon Cancer CT26 Cells via the MAPK Pathway.Molecules (Basel, Switzerland) · 2023Article
- Association between wine consumption and cancer: a systematic review and meta-analysis.Frontiers in nutrition · 2023Review
- Review
- Effects of low-to-moderate ethanol consumption on colonic growth and gene expression in young adult and middle-aged male rats.PloS one · 2020Article
- Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages.Nutrients · 2018Article
- Polyphenol Extracts from Red Wine and Grapevine: Potential Effects on Cancers.Diseases (Basel, Switzerland) · 2018Review
- Association between Nutrient Intake and Metabolic Syndrome in Patients with Colorectal Cancer.Clinical nutrition research · 2017Article
- Low bone mineral density linked to colorectal adenomas: a cross-sectional study of a racially diverse population.Journal of gastrointestinal oncology · 2015Article
- Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival.Alcohol research : current reviews · 2015Review
- Interaction between alcohol drinking and obesity in relation to colorectal cancer risk: a case-control study in Newfoundland and Labrador, Canada.BMC public health · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe relationship between alcohol intake and rectal cancer is uncertain.
objectiveWe sought to evaluate whether alcohol consumption is associated with distal colorectal cancer and rectal cancer specifically.
designData on alcohol intake were examined from the North Carolina Colon Cancer Study, a population-based case-control study of distal colorectal cancer.
settingThis study encompassed 33 counties in the central and eastern part of North Carolina. PATIENTS: Cases had adenocarcinoma of the rectum, rectosigmoid, and sigmoid colon. Controls were frequency-matched on age, race, and sex.
interventionsDemographic and dietary intake data were collected with use of a validated questionnaire.
main outcome measuresLogistic regression was used to estimate odds ratios for the relationship between alcohol consumption and distal colorectal cancer.
resultsIncluded in the study were 1033 cases and 1011 controls. The odds ratio for rectal cancer comparing any vs no alcohol intake was 0.73 (95% CI 0.60, 0.90), adjusted for age, sex, race, smoking status, obesity, education, red meat intake, use of nonsteroidal anti-inflammatory medications, and family history of colorectal cancer. The odds ratio for moderate alcohol (≤14 g/day) was 0.66 (95% CI 0.53, 0.82), whereas the odds ratio for heavy alcohol (>14 g/day) was 0.93 (95% CI 0.70, 1.23). Moderate beer and wine intakes were also inversely associated with distal colorectal cancer: odds ratios 0.76 (95% CI 0.60, 0.96) and 0.69 (95% CI 0.56, 0.86). LIMITATIONS: This was a retrospective, observational study. Residual confounding is possible.
conclusionsIn this study, moderate alcohol intake (especially wine) was inversely associated with distal colorectal cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.