ArticleBlood2011
Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.
Article in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- A cohesin traffic pattern genetically linked to gene regulation.Nature structural & molecular biology · 2022Article
- Generation of a mouse model of the neurodevelopmental disorder with dysmorphic facies and distal limb anomalies syndrome.Human molecular genetics · 2022Article
- Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF.Current opinion in chemical biology · 2021Review
- Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis.Nucleic acids research · 2020Article
- SET domain containing 1B gene is mutated in primary hepatic neuroendocrine tumors.International journal of cancer · 2019Article
- Transcription termination sequences support the expression of transgene product secreted with milk.Transgenic research · 2019Article
- Histone H3 lysine 9 acetylation is downregulated in GDM Placentas and Calcitriol supplementation enhanced this effect.International journal of molecular sciences · 2018Article
- Ten principles of heterochromatin formation and function.Nature reviews. Molecular cell biology · 2018Review
- Catching global interactions in vivo.Cell & bioscience · 2017Article
- Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation.Nucleic acids research · 2016Article
- EYA1 expression and subcellular localization in neuroblastoma and its association with prognostic markers.Journal of cancer research & therapy · 2016Article
- Genome-Wide Mapping Targets of the Metazoan Chromatin Remodeling Factor NURF Reveals Nucleosome Remodeling at Enhancers, Core Promoters and Gene Insulators.PLoS genetics · 2016Article
- HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development.Cell reports · 2016Article
- Chromatin rules.Stem cell investigation · 2016Article
- Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains.Genome research · 2016Article
- Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex.PLoS pathogens · 2014Article
- Aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia.Leukemia · 2014Article
- hSETD1A regulates Wnt target genes and controls tumor growth of colorectal cancer cells.Cancer research · 2014Article
- Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.Cell reports · 2014Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
Chromatin insulators protect erythroid genes from being silenced during erythropoiesis, and the disruption of barrier insulator function in erythroid membrane gene loci results in mild or severe anemia. We showed previously that the USF1/2-bound 5'HS4 insulator mediates chromatin barrier activity in the erythroid-specific chicken β-globin locus. It is currently not known how insulators establish such a barrier. To understand the function of USF1, we purified USF1-associated protein complexes and found that USF1 forms a multiprotein complex with hSET1 and NURF, thus exhibiting histone H3K4 methyltransferase- and ATP-dependent nucleosome remodeling activities, respectively. Both SET1 and NURF are recruited to the 5'HS4 insulator by USF1 to retain the active chromatin structure in erythrocytes. Knock-down of NURF resulted in a rapid loss of barrier activity accompanied by an alteration of nucleosome positioning, increased occupancy of the nucleosome-free linker region at the insulator site, and increased repressive H3K27me3 levels in the vicinity of the HS4 insulator. Furthermore, suppression of SET1 reduced barrier activity, decreased H3K4me2 and acH3K9/K14, and diminished the recruitment of BPTF at several erythroid-specific barrier insulator sites. Therefore, our data reveal a synergistic role of hSET1 and NURF in regulating the USF-bound barrier insulator to prevent erythroid genes from encroachment of heterochromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.