ArticleAmerican journal of respiratory cell and molecular biology2011
Mucin production during prenatal and postnatal murine lung development.
Article in American journal of respiratory cell and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 49 citations in OpenAlex.
- Lack of SLC26A9-mediated chloride secretion causes mucus plugging and severe respiratory distress in neonatal mice.JCI insight · 2025Article
- Bilateral orthotopic lung transplantation for the patient with lung-limited invasive mucinous adenocarcinoma: a case-based literature review.The oncologist · 2025Review
- Neuraminidase-mediated enhancement ofmBio · 2025Article
- Neonatal Immune Responses to Respiratory Viruses.Frontiers in immunology · 2022Review
- VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway.Developmental cell · 2021Article
- Concomitant deletion of HRAS and NRAS leads to pulmonary immaturity, respiratory failure and neonatal death in mice.Cell death & disease · 2019Article
- FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury.Stem cell reports · 2019Article
- Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2019Review
- Putting Mucins on the Map.American journal of respiratory and critical care medicine · 2019Article
- Building and Regenerating the Lung Cell by Cell.Physiological reviews · 2019Review
- Role of Spdef in the Regulation of Muc5b Expression in the Airways of Naive and Mucoobstructed Mice.American journal of respiratory cell and molecular biology · 2018Article
- Cell type specific expression of Follistatin-like 1 (Fstl1) in mouse embryonic lung development.Journal of molecular histology · 2018Article
- Role of mucins in lung homeostasis: regulated expression and biosynthesis in health and disease.Biochemical Society transactions · 2018Review
- Birth delivery method affects expression of immune genes in lung and jejunum tissue of neonatal beef calves.BMC veterinary research · 2017Article
- In vivo imaging of the Muc5b gel-forming mucin.Scientific reports · 2017Article
- Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.Mucosal immunology · 2017Article
- Neonatal mucosal immunology.Mucosal immunology · 2017Review
- Younger patients with COME are more likely to have mucoid middle ear fluid containing mucin MUC5B.International journal of pediatric otorhinolaryngology · 2016Article
- Control of lung defence by mucins and macrophages: ancient defence mechanisms with modern functions.The European respiratory journal · 2016Review
- Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways.Physiological reviews · 2016Review
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Mucus is a protective gel that lines respiratory tract surfaces. To identify potential roles for secreted gel--forming mucins in lung development, we isolated murine lungs on embryonic days (E) 12.5-18.5, and postnatal days (PN) days 5, 14, and 28. We measured the mucin gene expression by quantitative RT-PCR, and localization by histochemical and immunohistochemical labeling. Alcian blue/periodic acid--Schiff--positive cells are present from E15.5 through PN28. Muc5b transcripts were abundant at all time points from E14.5 to PN28. By contrast, transcript levels of Muc5ac and Muc2 were approximately 300 and 85,000 times lower, respectively. These data are supported by immunohistochemical studies demonstrating the production and localization of Muc5ac and Muc5b protein. This study indicates that mucin production is prominent in developing murine lungs and that Muc5b is an early, abundant, and persistent marker of bronchial airway secretory cells, thereby implicating it as an intrinsic component of homeostatic mucosal defense in the lungs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.