ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Transsynaptic EphB/Ephrin-B signaling regulates growth of presynaptic boutons required for classical conditioning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Anxiolytic reversal of classically conditioned / chronic stress-induced gene expression and learning in the Stress Alternatives Model.Behavioural brain research · 2023Article
- Comparative Genomics of the BDNF Gene, Non-Canonical Modes of Transcriptional Regulation, and Neurological Disease.Molecular neurobiology · 2021Review
- Synapsin regulates activity-dependent outgrowth of synaptic boutons at the Drosophila neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Behavioral improvement and regulation of molecules related to neuroplasticity in ischemic rat spinal cord treated with PEDF.Neural plasticity · 2014Article
- Cell biology in neuroscience: cellular and molecular mechanisms underlying presynapse formation.The Journal of cell biology · 2013Review
- Molecular mechanisms underlying the effects of acupuncture on neuropathic pain.Neural regeneration research · 2013Article
- Identification of a functionally distinct truncated BDNF mRNA splice variant and protein in Trachemys scripta elegans.PloS one · 2013Article
- Coordinated Eph-ephrin signaling guides migration and axon targeting in the avian auditory system.Neural development · 2012Article
- Two-stage AMPA receptor trafficking in classical conditioning and selective role for glutamate receptor subunit 4 (tGluA4) flop splice variant.Journal of neurophysiology · 2012Article
- Eph-dependent cell-cell adhesion and segregation in development and cancer.Cellular and molecular life sciences : CMLS · 2012Review
- Rapid enrichment of presynaptic protein in boutons undergoing classical conditioning is mediated by brain-derived neurotrophic factor.Neuroscience · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Learning-related presynaptic remodeling has been documented in only a few systems, and its molecular mechanisms are largely unknown. Here we describe a role for the bidirectional EphB/ephrin-B signaling system in structural plasticity of presynaptic nerve terminals using an in vitro model of classical conditioning. Conditioning or BDNF application induced significant growth of auditory nerve presynaptic boutons that convey the conditioned stimulus to abducens motor neurons. Interestingly, bouton enlargement occurred only for those synapses apposed to motor neuron dendrites rather than to somata. Phosphorylation of ephrin-B1, but not EphB2, was induced by both conditioning and BDNF application and was inhibited by postsynaptic injections of ephrin-B antibody. Finally, suppression of postsynaptic ephrin-B function inhibited presynaptic bouton enlargement that was rescued by activation of EphB2 by ephrin-B1-Fc. These data provide evidence for ephrin-B-induced EphB2 forward signaling in presynaptic structural plasticity during classical conditioning. They also reveal a functional interaction between BDNF/TrkB and the Eph/ephrin signaling systems in the coordination of presynaptic and postsynaptic modifications during conditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.