ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Initiation of locomotion in adult zebrafish.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 132 citations in OpenAlex.
- Connectivity of a Conspicuous Layered Structure in the Dorsal Telencephalon of the Peacock Gudgeon, Tateurndina ocellicauda.The Journal of comparative neurology · 2025Article
- Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord.iScience · 2025Article
- Variation in behavioral preference and calcium binding expression in twoFrontiers in neuroanatomy · 2025Article
- Diversification of pectoral control through motor pool extension.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish.eLife · 2024Article
- The Dorsal Part of the Anterior Tuberal Nucleus Responds to Auditory Stimulation in Zebrafish (eNeuro · 2024Article
- Undulatory Propulsion at Milliscale on Water Surface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Molecular blueprints for spinal circuit modules controlling locomotor speed in zebrafish.Nature neuroscience · 2024Article
- The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish.Nature neuroscience · 2023Article
- Linking neural circuits to the mechanics of animal behavior inFrontiers in neural circuits · 2023Review
- Superfast excitation-contraction coupling in adult zebrafish skeletal muscle fibers.The Journal of general physiology · 2022Article
- Transformation of an early-established motor circuit during maturation in zebrafish.Cell reports · 2022Article
- A specialized spinal circuit for command amplification and directionality during escape behavior.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Non-Rodent Genetic Animal Models for Studying Tauopathy: Review ofInternational journal of molecular sciences · 2021Review
- Current Methods to Investigate Nociception and Pain in Zebrafish.Frontiers in neuroscience · 2021Review
- Hypothalamic Pomc Neurons Innervate the Spinal Cord and Modulate the Excitability of Premotor Circuits.Current biology : CB · 2020Article
- Central and peripheral innervation patterns of defined axial motor units in larval zebrafish.The Journal of comparative neurology · 2019Article
- Reconciling the functions of even-skipped interneurons during crawling, swimming, and walking.Current opinion in physiology · 2019Article
- Principles Governing Locomotion in Vertebrates: Lessons From Zebrafish.Frontiers in neural circuits · 2018Review
- Delineating the Diversity of Spinal Interneurons in Locomotor Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor behavior is generated by specific neural circuits. Those producing locomotion are located in the spinal cord, and their activation depends on descending inputs from the brain or on sensory inputs. In this study, we have used an in vitro brainstem-spinal cord preparation from adult zebrafish to localize a region where stimulation of descending inputs can induce sustained locomotor activity. We show that a brief stimulation of descending inputs at the junction between the brainstem and spinal cord induces long-lasting swimming activity. The swimming frequencies induced are remarkably similar to those observed in freely moving adult fish, arguing that the induced locomotor episode is highly physiological. The motor pattern is mediated by activation of ionotropic glutamate and glycine receptors in the spinal cord and is not the result of synaptic interactions between neurons at the site of the stimulation in the brainstem. We also compared the activity of motoneurons during locomotor activity induced by electrical stimulation of descending inputs and by exogenously applied NMDA. Prolonged NMDA application changes the shape of the synaptic drive and action potentials in motoneurons. When escape activity occurs, the swimming activity in the intact zebrafish was interrupted and some of the motoneurons involved became inhibited in vitro. Thus, the descending inputs seem to act as a switch to turn on the activity of the spinal locomotor network in the caudal spinal cord. We propose that recurrent synaptic activity within the spinal locomotor circuits can transform a brief input into a well coordinated and long-lasting swimming pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.