Evidence map›Paper›PMID 21653769›Full record

ArticleJournal of clinical microbiology2011

Diagnostic consequences of cytomegalovirus glycoprotein B polymorphisms.

Zdenek Novak, Nazma Chowdhury, Shannon A Ross, Sunil K Pati, Karen Fowler, Suresh B Boppana

Open access · bronzeAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
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  4. Observational
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zdenek NovakUniversity of Alabama at Birmingham, Children's Hospital, CHB 150, 1600 6th Ave. S., Birmingham, AL 35233, USA. zdnovak@peds.uab.edu
Nazma Chowdhury
Shannon A Ross
Sunil K Pati
Karen Fowler
Suresh B Boppana
University of Alabama at Birmingham · US

Funding

NIDCD NIH HHS N01 DC050008
6 · The paper itself

Abstract

Failure of a cytomegalovirus (CMV) real-time PCR assay targeting glycoprotein B (gB) was investigated. A multiplex assay targeting gB and immediate-early 2 (IE2) genes showed discordant results (gB negative and IE positive or a >10-fold-higher viral load with IE primers) in saliva from 14.6% of CMV-infected newborns. Sequencing revealed 3 patterns of gB variations.

Indexed as

Polymorphism, GeneticCytomegalovirusCytomegalovirus InfectionsHumansImmediate-Early ProteinsInfantInfant, NewbornMolecular Diagnostic TechniquesReal-Time Polymerase Chain ReactionSalivaSensitivity and SpecificityTrans-ActivatorsViral Envelope ProteinsVirologyglycoprotein B, SimplexvirusIE2 protein, CytomegalovirusImmediate-Early ProteinsTrans-ActivatorsViral Envelope Proteins

Identifiers

PMID21653769
PMCPMC3147759
OpenAlexW2104541826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.