Evidence map›Paper›PMID 21653761›Full record

ArticleJournal of clinical microbiology2011

Controlled comparison of BacT/Alert MB system, manual Myco/F lytic procedure, and isolator 10 system for diagnosis of Mycobacterium tuberculosis Bacteremia.

John A Crump, Anne B Morrissey, Habib O Ramadhani, Boniface N Njau, Venance P Maro, L Barth Reller

Open access · greenAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Mycobacterium tuberculosis bacteremia in adults and children: a systematic review and meta-analysis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2016
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Point-of-critical-care diagnostics for sepsis enabled by multiplexed micro and nanosensing technologies.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021
    Review
  7. Article
  8. Review
  9. Article
  10. Diagnosis of active tuberculosis disease: From microscopy to molecular techniques.Journal of clinical tuberculosis and other mycobacterial diseases · 2016
    Review
  11. Review
  12. Article
  13. Article
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  15. Article
  16. Article
  17. Article
  18. Article
  19. Histoplasmosis among hospitalized febrile patients in northern Tanzania.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2012
    Article
  20. Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

John A CrumpBox 102359, Duke University Medical Center, Durham, NC 27710, USA. john.crump@duke.edu
Anne B Morrissey
Habib O Ramadhani
Boniface N Njau
Venance P Maro
L Barth Reller
Tumaini University · TZDuke University · USKilimanjaro Christian Medical Centre · TZ

Funding

Viral Sequencing CoreU19AI067854 · NIAID · DUKE UNIVERSITY · PI BHARDWAJ, NINA · 2006 to 2011
$290.5M
Viral and Host Determinants of HIV-1 TransmissionU01AI067854 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F · 2005 to 2005
$14.9M
HIV/AIDS Clinical Trials UnitU01AI069484 · NIAID · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2007 to 2011
$14.6M
International Clinical Trials UnitU01AI062563 · NIAID · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2004 to 2007
$4.0M
The Impact and Society Ecology of Bacterial Zoonoses in Northern Tanzania: UnderR01TW009237 · FIC · DUKE UNIVERSITY · PI CRUMP, JOHN ANDREW · 2011 to 2014
$1.7M
FIC NIH HHS R01 TW009237NIAID NIH HHS U01 AI062563NIAID NIH HHS U01 AI067854NIAID NIH HHS U01 AI069484NIAID NIH HHS U19 AI067854PHS HHS D43 PA-03-018)
6 · The paper itself

Abstract

We compared the performance of the BacT/Alert MB system, that of the manual Bactec Myco/F Lytic procedure, and that of the Isolator 10 lysis-centrifugation system in the detection of Mycobacterium tuberculosis bacteremia. Mean times to detection were 16.4 days for BacT/Alert MB versus 20.0 days for Myco/F Lytic, 16.5 days for BacT/Alert MB versus 23.8 days for Isolator 10, and 21.1 days for Bactec Myco/F Lytic versus 22.7 days for Isolator 10. There were no significant differences in yields. The mean (range) magnitude of mycobacteremia was 30.0 (0.4, 90.0) CFU/ml and was correlated with the time to positivity in the BacT/Alert MB system (r = -0.4920). M. tuberculosis bacteremia was detected more rapidly in a continuously monitored liquid blood culture system, but the mean time to positivity exceeded 3 weeks.

Indexed as

AdolescentAdultAgedAged, 80 and overBacteremiaBacteriological TechniquesHumansMiddle AgedMycobacterium tuberculosisSensitivity and SpecificityTime FactorsTuberculosisYoung Adult

Identifiers

PMID21653761
PMCPMC3147725
OpenAlexW2007073808

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.