ArticleJournal of neurophysiology2011
Development of new peptide-based tools for studying synaptic ribbon function.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Synaptic ribbon dynamics after noise exposure in the hearing cochlea.Communications biology · 2024Article
- Role of Ribeye PXDLS/T-binding cleft in normal synaptic ribbon function.bioRxiv : the preprint server for biology · 2023Article
- A sensory cell diversifies its output by varying CaThe EMBO journal · 2021Article
- Phase-Locking Requires Efficient CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Endocytosis sustains release at photoreceptor ribbon synapses by restoring fusion competence.The Journal of general physiology · 2018Article
- Compartmentalization of antagonistic CaProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Quantitative optical nanophysiology of CaNature communications · 2018Article
- Two Pools of Vesicles Associated with Synaptic Ribbons Are Molecularly Prepared for Release.Biophysical journal · 2017Article
- RIM-Binding Protein 2 Promotes a Large Number of CaFrontiers in cellular neuroscience · 2017Article
- The zebrafish pinball wizard gene encodes WRB, a tail-anchored-protein receptor essential for inner-ear hair cells and retinal photoreceptors.The Journal of physiology · 2016Article
- Nanoscale dynamics of synaptic vesicle trafficking and fusion at the presynaptic active zone.eLife · 2016Article
- Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- ATP hydrolysis is critically required for function of CaV1.3 channels in cochlear inner hair cells via fueling Ca2+ clearance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis.The EMBO journal · 2014Article
- Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Patch-clamp recordings from lateral line neuromast hair cells of the living zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Properties of ribbon and non-ribbon release from rod photoreceptors revealed by visualizing individual synaptic vesicles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Synaptic ribbons are proteinaceous specialized electron-dense presynaptic structures found in nonspiking sensory cells of the vertebrate nervous system. Understanding the function of these structures is an active area of research (reviewed in Matthews G, Fuchs P. Nat Rev Neurosci 11: 812-822, 2010). Previous work had shown that ribbons could be effectively labeled and visualized using peptides that bind to the synaptic ribbon protein RIBEYE via a PXDLS motif (Zenisek D, Horst NK, Merrifield C, Sterling P, Matthews G. J Neurosci 24: 9752-9759, 2004). Here, we expand on the previous work to develop new tools and strategies for 1) better visualizing synaptic ribbons, and 2) monitoring and manipulating calcium on the synaptic ribbon. Specifically, we developed a new higher-affinity peptide-based label for visualizing ribbons in live cells and two strategies for localizing calcium indicators to the synaptic ribbon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.