ArticleThe Journal of biological chemistry2011
Contribution of retinoid X receptor signaling to the specification of skeletal muscle lineage.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Cistromic insight into the association of retinoid X receptor with MyoD and CTCF in proliferating myoblasts.Scientific reports · 2025Article
- Exploring the Regulation ofJournal of developmental biology · 2025Article
- Regulation of Dystroglycan Gene Expression in Early Myoblast Differentiation.Frontiers in cell and developmental biology · 2022Article
- ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.Developmental cell · 2021Article
- Vitamin A regulates intramuscular adipose tissue and muscle development: promoting high-quality beef production.Journal of animal science and biotechnology · 2021Review
- Multi-Omics Approach to Dissect the Mechanisms of Rexinoid Signaling in Myoblast Differentiation.Frontiers in pharmacology · 2021Article
- Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers.Journal of animal science and biotechnology · 2018Article
- Loci-specific histone acetylation profiles associated with transcriptional coactivator p300 during early myoblast differentiation.Epigenetics · 2018Article
- Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro.Experimental cell research · 2017Article
- Insights into interplay between rexinoid signaling and myogenic regulatory factor-associated chromatin state in myogenic differentiation.Nucleic acids research · 2017Article
- Retinoid X Receptor Activation Alters the Chromatin Landscape To Commit Mesenchymal Stem Cells to the Adipose Lineage.Endocrinology · 2017Article
- Gene expression profiling discerns molecular pathways elicited by ligand signaling to enhance the specification of embryonic stem cells into skeletal muscle lineage.Cell & bioscience · 2017Review
- Retinoid X Receptor-selective Signaling in the Regulation of Akt/Protein Kinase B Isoform-specific Expression.The Journal of biological chemistry · 2016Article
- Implication of retinoic acid receptor selective signaling in myogenic differentiation.Scientific reports · 2016Article
- Molecular Basis for the Regulation of Transcriptional Coactivator p300 in Myogenic Differentiation.Scientific reports · 2015Article
- Effects of histone deacetylase inhibitor valproic acid on skeletal myocyte development.Scientific reports · 2014Article
- Activation of GATA4 gene expression at the early stage of cardiac specification.Frontiers in chemistry · 2014Article
- Enhancing myogenic differentiation of pluripotent stem cells with small molecule inducers.Cell & bioscience · 2013Article
- Differential effects of retinoids and inhibitors of ERK and p38 signaling on adipogenic and myogenic differentiation of P19 stem cells.Stem cells and development · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Pluripotent stem cells possess a tremendous potential for the treatment of many diseases because of their capacity to differentiate into a variety of cell lineages. However, they provide little promise for muscle-related diseases, mainly because of the lack of small molecule inducers to efficiently direct myogenic conversion. Retinoic acid, acting through the retinoic acid receptor (RAR) and retinoid X receptor (RXR), affects stem cell fate determination in a concentration-dependent manner, but it only has a modest efficacy on the commitment of ES cells into skeletal muscle lineage. The RXR is very important for embryonic development but is generally considered to act as a silent partner of RAR in a non-permissive mode. In this study, we have examined whether activation of the RXR by rexinoid or RXR-specific signaling play a role in the specification of stem cells into muscle lineage. Our findings demonstrate that mouse ES cells generate skeletal myocytes effectively upon treatment with rexinoid at the early stage of differentiation and that on a molecular level, rexinoid-enhanced myogenesis simulates the sequential events observed in vivo. Moreover, RXR-mediated myogenic conversion requires the function of β-catenin but not RAR. Our studies establish the feasibility of applying the RXR agonist in cell-based therapies to treat muscle-related diseases. The aptitude of mouse ES cells to generate skeletal myocytes following rexinoid induction also provides a model system to study the convergence of different signaling pathways in myogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.