ArticleDevelopment (Cambridge, England)2011
Serial specification of diverse neuroblast identities from a neurogenic placode by Notch and Egfr signaling.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Homeodomain protein Six4 prevents the generation of supernumerary Drosophila type II neuroblasts and premature differentiation of intermediate neural progenitors.PLoS genetics · 2021Article
- Glial and Neuronal Neuroglian, Semaphorin-1a and Plexin A Regulate Morphological and Functional Differentiation ofFrontiers in endocrinology · 2021Article
- Histone deacetylase (Rpd3) regulatesOpen biology · 2020Article
- Expression of Mammalian BM88/CEND1 in Drosophila Affects Nervous System Development by Interfering with Precursor Cell Formation.Neuroscience bulletin · 2019Article
- Review
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- Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer.Cancers · 2017Review
- Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche.Development (Cambridge, England) · 2016Article
- Article
- Insight into insulin secretion from transcriptome and genetic analysis of insulin-producing cells of Drosophila.Genetics · 2014Article
- Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling.PLoS genetics · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We used the brain insulin-producing cell (IPC) lineage and its identified neuroblast (IPC NB) as a model to understand a novel example of serial specification of NB identities in the Drosophila dorsomedial protocerebral neuroectoderm. The IPC NB was specified from a small, molecularly identified group of cells comprising an invaginated epithelial placode. By progressive delamination of cells, the placode generated a series of NB identities, including the single IPC NB, a number of other canonical Type I NBs, and a single Type II NB that generates large lineages by transient amplification of neural progenitor cells. Loss of Notch function caused all cells of the placode to form as supernumerary IPC NBs, indicating that the placode is initially a fate equivalence group for the IPC NB fate. Loss of Egfr function caused all placodal cells to apoptose, except for the IPC NB, indicating a requirement of Egfr signaling for specification of alternative NB identities. Indeed, both derepressed Egfr activity in yan mutants and ectopic EGF activity produced supernumerary Type II NBs from the placode. Loss of both Notch and Egfr function caused all placode cells to become IPC NBs and survive, indicating that commitment to NB fate nullified the requirement of Egfr activity for placode cell survival. We discuss the surprising parallels between the serial specification of neural fates from this neurogenic placode and the fly retina.
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