ArticleBiology letters2011
Explaining the heritability of an ecologically significant trait in terms of individual quantitative trait loci.
Article in Biology letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Genomics of Experimental Adaptive Radiation in the Cryptic Coloration of Feather Lice.Genome biology and evolution · 2025Article
- Estimating genetic variance contributed by a quantitative trait locus: A random model approach.PLoS computational biology · 2022Article
- The role of population and quantitative genetics and modern sequencing technologies to understand evolved herbicide resistance and weed fitness.Pest management science · 2021Article
- Extreme copy number variation at a tRNA ligase gene affecting phenology and fitness in yellow monkeyflowers.Molecular ecology · 2019Article
- Population structure and local selection yield high genomic variation in Mimulus guttatus.Molecular ecology · 2017Article
- Transgenerational plasticity is sex-dependent and persistent in yellow monkeyflower (Environmental epigenetics · 2016Article
- The genetic architecture of sexually selected traits in two natural populations of Drosophila montana.Heredity · 2015Article
- Centromere-associated meiotic drive and female fitness variation in Mimulus.Evolution; international journal of organic evolution · 2015Article
- The genomic signal of partial sweeps in Mimulus guttatus.Genome biology and evolution · 2013Article
- Spatially and temporally varying selection on intrapopulation quantitative trait loci for a life history trade-off in Mimulus guttatus.Molecular ecology · 2012Article
- Interactions among flower-size QTL of Mimulus guttatus are abundant but highly variable in nature.Genetics · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Most natural populations display substantial genetic variation in behaviour, morphology, physiology, life history and the susceptibility to disease. A major challenge is to determine the contributions of individual loci to variation in complex traits. Quantitative trait locus (QTL) mapping has identified genomic regions affecting ecologically significant traits of many species. In nearly all cases, however, the importance of these QTLs to population variation remains unclear. In this paper, we apply a novel experimental method to parse the genetic variance of floral traits of the annual plant Mimulus guttatus into contributions of individual QTLs. We first use QTL-mapping to identify nine loci and then conduct a population-based breeding experiment to estimate V(Q), the genetic variance attributable to each QTL. We find that three QTLs with moderate effects explain up to one-third of the genetic variance in the natural population. Variation at these loci is probably maintained by some form of balancing selection. Notably, the largest effect QTLs were relatively minor in their contribution to heritability.
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