ArticleEuropean heart journal2012
Rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of British men and women in the Whitehall II cohort.
Article in European heart journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Temporal trend in dementia incidence since 2002 and projections for prevalence in England and Wales to 2040: modelling study.BMJ (Clinical research ed.) · 2017Article
- Social factors and cardiovascular morbidity.Neuroscience and biobehavioral reviews · 2017Review
- Impact of variants in CETP and apo AI genes on serum HDL cholesterol levels in men and women from the Polish population.Archives of medical science : AMS · 2016Article
- Ischemic Stroke Rate Increases in Young Adults: Evidence for a Generational Effect?Journal of the American Heart Association · 2016Article
- Trends in Coronary Atherosclerosis: A Tale of Two Population Subgroups.The American journal of medicine · 2016Article
- Contributions of increasing obesity and diabetes to slowing decline in subclinical coronary artery disease.Journal of the American Heart Association · 2015Article
- Association of body mass index and waist circumference with successful aging.Obesity (Silver Spring, Md.) · 2014Article
- Defending the con side: obesity paradox does not exist.Diabetes care · 2013Article
- Cardiovascular consequences of obesity: how will the UK cope?Drugs in context · 2013Article
- Contribution of modifiable risk factors to social inequalities in type 2 diabetes: prospective Whitehall II cohort study.BMJ (Clinical research ed.) · 2012Article
- Coding, recording and incidence of different forms of coronary heart disease in primary care.PloS one · 2012Article
- Interventions to promote an integrated approach to public health problems: an application to childhood obesity.Journal of environmental and public health · 2012Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
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Abstract
Aims To estimate the contribution of risk factor trends to 20-year declines in myocardial infarction (MI) incidence in British men and women. Methods and results From 1985 to 2004, 6379 men and 3074 women in the Whitehall II cohort were followed for incident MI and risk factor trends. Over 20 years, the age-sex-adjusted hazard of MI fell by 74% (95% confidence interval 48-87%), corresponding to an average annual decline of 6.5% (3.2-9.7%). Thirty-four per cent (20-76%) of the decline in MI hazard could be statistically explained by declining non-HDL cholesterol levels, followed by increased HDL cholesterol (17%, 10-32%), reduced systolic blood pressure (13%, 7-24%), and reduced cigarette smoking prevalence (6%, 2-14%). Increased fruit and vegetable consumption made a non-significant contribution of 7% (-1-20%). In combination, these five risk factors explained 56% (34-112%). Rising body mass index (BMI) was counterproductive, reducing the scale of the decline by 11% (5-23%) in isolation. The MI decline and the impact of the risk factors appeared similar for men and women. Conclusion In men and women, over half of the decline in MI risk could be accounted for by favourable risk factor time trends. The adverse role of BMI emphasizes the importance of addressing the rising population BMI.
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