Evidence map›Paper›PMID 21653532›Full record

ReviewProceedings of the American Thoracic Society2011

Critical illness in HIV-infected patients in the era of combination antiretroviral therapy.

Kathleen M Akgün, Laurence Huang, Alison Morris, Amy C Justice, Margaret Pisani, Kristina Crothers

Abstract readReview
In one paragraph

Review in Proceedings of the American Thoracic Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  4. Observational
  5. Article
  6. Article
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  11. Observational
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Kathleen M AkgünVA Connecticut Healthcare System, Department of Internal Medicine, West Haven, Connecticut, USA.
Laurence Huang
Alison Morris
Amy C Justice
Margaret Pisani
Kristina Crothers
Yale University · USSan Francisco General Hospital · USUniversity of Pittsburgh · USUniversity of Washington · US

Funding

Alcohol Associated Outcomes Among HIV+/-Aging VeteransU01AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2002 to 2005
$10.1M
Longitudinal Studies of HIV-Associated Lung Infections and ComplicationsR01HL090342 · NHLBI · YALE UNIVERSITY · PI CROTHERS, KRISTINA ANNE · 2007 to 2011
$4.0M
Prevalence & Pathogenesis of Pulmonary Disease in a Large Multicenter HIV CohortR01HL090339 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MORRIS, ALISON · 2007 to 2011
$4.0M
International HIV-associated Opportunistic Pneumonias (IHOP) StudyR01HL090335 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2007 to 2011
$4.0M
Patient-Oriented Research and Mentoring in PneumocystisK24HL087713 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2006 to 2018
$1.8M
NHLBI NIH HHS K24 HL 087713NHLBI NIH HHS R01 HL 090335NHLBI NIH HHS R01 HL090339NHLBI NIH HHS R01 HL090342NIAAA NIH HHS 5 U01AA013566-05
6 · The paper itself

Abstract

As HIV-infected persons on combination antiretroviral therapy (ART) are living longer and rates of opportunistic infections have declined, serious non-AIDS-related diseases account for an increasing proportion of deaths. Consistent with these changes, non-AIDS-related illnesses account for the majority of ICU admissions in more recent studies, in contrast to earlier eras of the AIDS epidemic. Although mortality after ICU admission has improved significantly since the earliest HIV era, it remains substantial. In this article, we discuss the current state of knowledge regarding the impact of ART on incidence, etiology, and outcomes of critical illness among HIV-infected patients. In addition, we consider issues related to administration of ART in the ICU and identify important areas of future research.

Indexed as

AIDS-Related Opportunistic InfectionsAnti-Retroviral AgentsAPACHECritical IllnessHealth Services AccessibilityHIV InfectionsHospital MortalityHumansIncidenceIntensive Care UnitsMedically UninsuredPatient AdmissionPneumonia, PneumocystisQuality of LifeRisk FactorsSurvival AnalysisAnti-Retroviral Agents

Identifiers

PMID21653532
PMCPMC3132789
OpenAlexW2109127457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.