Evidence map›Paper›PMID 21653531›Full record

ReviewProceedings of the American Thoracic Society2011

HIV-associated Pneumocystis pneumonia.

Laurence Huang, Adithya Cattamanchi, J Lucian Davis, Saskia den Boon, Joseph Kovacs, Steven Meshnick, Robert F Miller, Peter D Walzer, William Worodria, Henry Masur and 2 more

Abstract readReview
In one paragraph

Review in Proceedings of the American Thoracic Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 4 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 190 citations in OpenAlex.

  1. Trimethoprim-Sulfamethoxazole (Bactrim) Dose Optimization inInternational journal of environmental research and public health · 2022
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Immune responses of different hosts toEuropean respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  11. The Efficacy of Cotrimoxazole for the Prevention ofEpidemiologia (Basel, Switzerland) · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Metabolic modulation:Cell surface (Amsterdam, Netherlands) · 2024
    Review
  16. Article
  17. Clinical microbiology reviews · 2024
    Review
  18. Molecular Analysis of Dihydropteroate Synthase Gene Mutations inInternational journal of molecular sciences · 2023
    Article
  19. Article
  20. Long-term Outcomes of Patients With HIV andOpen forum infectious diseases · 2023
    Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Laurence HuangDivision of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA. lhuang@php.ucsf.edu
Adithya Cattamanchi
J Lucian Davis
Saskia den Boon
Joseph Kovacs
Steven Meshnick
Robert F Miller
Peter D Walzer
William Worodria
Henry Masur
International HIV-associated Opportunistic Pneumonias (IHOP) Study
Lung HIV Study
University of California, San Francisco · USNational Institutes of Health · USCincinnati VA Medical Center · USLondon School of Hygiene & Tropical Medicine · GBMulago Hospital · UGSan Francisco General Hospital · USUniversity of North Carolina at Chapel Hill · US

Funding

International HIV-associated Opportunistic Pneumonias (IHOP) StudyR01HL090335 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2007 to 2011
$4.0M
Patient-Oriented Research and Mentoring in PneumocystisK24HL087713 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2006 to 2018
$1.8M
Immunodiagnosis of Active Tuberculosis in HIV-infected PatientsK23HL094141 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CATTAMANCHI, ADITHYA · 2009 to 2013
$760k
NHLBI NIH HHS HL087713NHLBI NIH HHS HL090335NHLBI NIH HHS HL090335-02S1NHLBI NIH HHS K23 HL094141NHLBI NIH HHS K24 HL087713NHLBI NIH HHS R01 HL090335
6 · The paper itself

Abstract

During the past 30 years, major advances have been made in our understanding of HIV/AIDS and Pneumocystis pneumonia (PCP), but significant gaps remain. Pneumocystis is classified as a fungus and is host-species specific, but an understanding of its reservoir, mode of transmission, and pathogenesis is incomplete. PCP remains a frequent AIDS-defining diagnosis and is a frequent opportunistic pneumonia in the United States and in Europe, but comparable epidemiologic data from other areas of the world that are burdened with HIV/AIDS are limited. Pneumocystis cannot be cultured, and bronchoscopy with bronchoalveolar lavage is the gold standard procedure to diagnose PCP, but noninvasive diagnostic tests and biomarkers show promise that must be validated. Trimethoprim-sulfamethoxazole is the recommended first-line treatment and prophylaxis regimen, but putative trimethoprim-sulfamethoxazole drug resistance is an emerging concern. The International HIV-associated Opportunistic Pneumonias (IHOP) study was established to address these knowledge gaps. This review describes recent advances in the pathogenesis, epidemiology, diagnosis, and management of HIV-associated PCP and ongoing areas of clinical and translational research that are part of the IHOP study and the Longitudinal Studies of HIV-associated Lung Infections and Complications (Lung HIV).

Indexed as

Adrenal Cortex HormonesAIDS-Related Opportunistic InfectionsAnti-Infective Agentsbeta-GlucansBiomarkersBronchoalveolar LavageBronchoscopyCD4 Lymphocyte CountDihydropteroate SynthaseDrug Resistance, FungalHIV InfectionsHumansMutationPneumocystis cariniiPneumonia, PneumocystisPneumothoraxAdrenal Cortex HormonesAnti-Infective Agentsbeta-GlucansBiomarkersDihydropteroate SynthaseS-AdenosylmethionineTetrahydrofolate DehydrogenaseTrimethoprim, Sulfamethoxazole Drug Combination

Identifiers

PMID21653531
PMCPMC3132788
OpenAlexW2036199624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.