Evidence map›Paper›PMID 21653530›Full record

ReviewProceedings of the American Thoracic Society2011

Epidemiology of tuberculosis and HIV: recent advances in understanding and responses.

Neil A Martinson, Christopher J Hoffmann, Richard E Chaisson

Abstract readReview
In one paragraph

Review in Proceedings of the American Thoracic Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The Role of Dendritic Cells in TB and HIV Infection.Journal of clinical medicine · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. [Pseudotumoral ocular tuberculosis: about 2 cases].The Pan African medical journal · 2020
    Article
  15. Article
  16. Article
  17. Airway CD8Frontiers in immunology · 2019
    Article
  18. Article
  19. Plasma Indoleamine 2, 3-Dioxygenase, a Biomarker for Tuberculosis in Human Immunodeficiency Virus-Infected Patients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Article
  20. The global HIV epidemic: What the pathologist needs to know.Seminars in diagnostic pathology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Neil A MartinsonCenter for TB Research, Johns Hopkins University School of Medicine, Baltimore Maryland 21231, USA. martinson@phru.co.za
Christopher J Hoffmann
Richard E Chaisson
Johns Hopkins University · US

Funding

Novel TB Prevention Regimens for HIV-Infected AdultsR01AI048526 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CHAISSON, RICHARD E. · 2001 to 2008
$5.5M
Longitudinal Study of HIV-Associated Lung Infections in SowetoR01HL090312 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CHAISSON, RICHARD E. · 2007 to 2012
$3.3M
CAUSES OF AND ASSOCIATIONS WITH DEATH DURING LONG TERM HAART IN AFRICAK23AI083099 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HOFFMANN, CHRISTOPHER J · 2010 to 2014
$671k
NHLBI NIH HHS HL90312NHLBI NIH HHS R01 HL090312NIAID NIH HHS AI48526NIAID NIH HHS K23 AI083099PHS HHS 2RTW007370PHS HHS 2RTW007373
6 · The paper itself

Abstract

Although tuberculosis (TB) continues to cause enormous suffering and overwhelm health care systems in areas with high HIV prevalence, there have been a number of recent significant advances in knowledge regarding the epidemiology, management, and control of HIV-related TB. TB remains the most common serious opportunistic infection in people with HIV infection and the leading cause of death. However, there is some reason for optimism. First, two trials addressing when to start antiretroviral therapy (ART) in HIV-infected adults with newly diagnosed TB have shown that earlier initiation of ART reduces mortality significantly. Second, there is trial evidence of efficacy in giving long-term isoniazid preventive treatment (IPT) to HIV-infected adults in high HIV-prevalence settings where TB reinfection is frequent (much like cotrimoxazole). Third, the search for an inexpensive, rapid, sensitive, and specific TB diagnostic that is able to replace smear and delayed mycobacterial culture has yielded promising results. Responding to massive TB epidemics in high HIV-prevalence settings, the World Health Organization has supplemented its directly observed treatment short-course strategy with one called the 3I's to actively screen and diagnose TB cases (intensified case finding), prevent new cases of TB with IPT, and prevent transmission of TB in congregate settings such as hospitals and clinics (infection control). Combating TB in high HIV-prevalence settings requires rapid and massive implementation of the 3I's with initiation of antiretrovirals and more effective efforts to prevent new HIV infections.

Indexed as

AIDS-Related Opportunistic InfectionsAntigens, BacterialAnti-Retroviral AgentsAntitubercular AgentsCD4 Lymphocyte CountClinical Trials as TopicHIV InfectionsHumansInfection ControlIsoniazidLipopolysaccharidesPolymerase Chain ReactionReagent StripsRisk FactorsSputumTuberculosisAntigens, BacterialAnti-Retroviral AgentsAntitubercular AgentsIsoniazidlipoarabinomannanLipopolysaccharidesReagent Strips

Identifiers

PMID21653530
PMCPMC3132787
OpenAlexW1987163502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.