ArticleJournal of leukocyte biology2011
Systemic mast cell degranulation increases mortality during polymicrobial septic peritonitis in mice.
Article in Journal of leukocyte biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Beyond the numbers: Critical analysis of the role of postmortem tryptase in the forensic diagnosis of anaphylaxis.Journal of forensic sciences · 2025Pooled it
- IL-18-associated basophil and mast cell activation in sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Developments in Mast Cell Research.The Journal of allergy and clinical immunology · 2026Review
- Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice.Nature communications · 2025Article
- The development of murine bone marrow-derived mast cells expressing functional human MRGPRX2 forFrontiers in immunology · 2024Article
- Diagnostic and prognostic value of autophagy-related key genes in sepsis and potential correlation with immune cell signatures.Frontiers in cell and developmental biology · 2023Article
- Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles.Frontiers in immunology · 2021Review
- Lactic Acid Inhibits Lipopolysaccharide-Induced Mast Cell Function by Limiting Glycolysis and ATP Availability.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Mast Cells in Viral, Bacterial, and Fungal Infection Immunity.International journal of molecular sciences · 2019Review
- Mast cell degranulation impairs pneumococcus clearance in miceThe World Allergy Organization journal · 2019Article
- Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic Cardiomyopathy.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2019Article
- The contribution of mast cells to bacterial and fungal infection immunity.Immunological reviews · 2018Review
- Nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide.The Journal of allergy and clinical immunology · 2016Article
- Mast cells play an important role in chlamydia pneumoniae lung infection by facilitating immune cell recruitment into the airway.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Perioperative organ injury.Anesthesiology · 2013Review
- Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest.Critical care medicine · 2013Article
- Innate immunity and its regulation by mast cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Review
- Inflection points in sepsis biology: from local defense to systemic organ injury.American journal of physiology. Lung cellular and molecular physiology · 2012Review
- Plasticity in mast cell responses during bacterial infections.Current opinion in microbiology · 2012Review
- The role of mast cells in the defence against pathogens.PLoS pathogens · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
MCs are required for an effective host response during septic peritonitis. Local MC degranulation facilitates neutrophil recruitment, activation, and bacterial killing. However, the role of MCs located distant from the site of infection is unknown. We studied the temporal and spacial degranulation of MCs following CLP-induced septic peritonitis. The functional importance of systemic MC degranulation during infection was evaluated by compartment-specific MC reconstitution. Serum histamine, reflecting MC degranulation, was elevated 4 h after onset of septic peritonitis. Histologic examination revealed progressive MC degranulation in select tissues during the first 24 h of infection. MC-deficient Wsh mice, reconstituted only in the peritoneal compartment, had improved survival after CLP compared with controls. However, reconstitution in peritoneal plus systemic compartments worsened survival after CLP. IL-6 contributed to the detrimental effects of systemic MCs on survival, as mice systemically reconstituted with IL-6(-/-) MCs were more likely to survive than control mice. These results indicate that in contrast to the benefits of local MC activation during infection, systemic MC activation worsens survival during CLP-induced sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.