ArticleThe Plant cell2011
Parameters affecting telomere-mediated chromosomal truncation in Arabidopsis.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- Past innovations and future possibilities in plant chromosome engineering.Plant biotechnology journal · 2025Review
- Distinct mechanisms for genomic attachment of the 5' and 3' ends of Agrobacterium T-DNA in plants.Nature plants · 2022Article
- Biocircuits in plants and eukaryotic algae.Frontiers in plant science · 2022Review
- Artificial chromosome technology and its potential application in plants.Frontiers in plant science · 2022Review
- Precise Characterization and Tracking of Stably Inherited Artificial Minichromosomes Made by Telomere-Mediated Chromosome Truncation inFrontiers in plant science · 2021Article
- Genetic and epigenetic effects on centromere establishment.Chromosoma · 2020Review
- Plant artificial chromosome technology and its potential application in genetic engineering.Plant biotechnology journal · 2016Review
- Engineering of plant chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Engineered minichromosomes in plants.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Atypical centromeres in plants-what they can tell us.Frontiers in plant science · 2015Review
- Minichromosomes and artificial chromosomes in Arabidopsis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Review
- Advanced genetic tools for plant biotechnology.Nature reviews. Genetics · 2013Review
- De novo generation of plant centromeres at tandem repeats.Chromosoma · 2013Article
- In vivo modification of a maize engineered minichromosome.Chromosoma · 2013Article
- Retrotransposon insertion targeting: a mechanism for homogenization of centromere sequences on nonhomologous chromosomes.Genes & development · 2012Article
- Telomere-mediated truncation of barley chromosomes.Chromosoma · 2012Article
- Characterization of a PDK1 homologue from the moss Physcomitrella patens.Plant physiology · 2012Article
- Surprises from the chromosome front: lessons from Arabidopsis on telomeres and telomerase.Cold Spring Harbor symposia on quantitative biology · 2012Article
- De novo telomere formation in Arabidopsis tetraploids.The Plant cell · 2011Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Conversion of a double-strand break into a telomere is a dangerous, potentially lethal event. However, little is known about the mechanism and control of de novo telomere formation (DNTF). DNTF can be instigated by the insertion of a telomere repeat array (TRA) into the host genome, which seeds the formation of a new telomere, resulting in chromosome truncation. Such events are rare and concentrated at chromosome ends. Here, we introduce tetraploid Arabidopsis thaliana as a robust genetic model for DNTF. Transformation of a 2.6-kb TRA into tetraploid plants resulted in a DNTF efficiency of 56%, fivefold higher than in diploid plants and 50-fold higher than in human cells. DNTF events were recovered across the entire genome, indicating that genetic redundancy facilitates recovery of DNTF events. Although TRAs as short as 100 bp seeded new telomeres, these tracts were unstable unless they were extended above a 1-kb size threshold. Unexpectedly, DNTF efficiency increased in plants lacking telomerase, and DNTF rates were lower in plants null for Ku70 or Lig4, components of the nonhomologous end-joining repair pathway. We conclude that multiple competing pathways modulate DNTF, and that tetraploid Arabidopsis will be a powerful model for elucidating the molecular details of these processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.