ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2011
Mimicking the inflammatory cell adhesion cascade by nucleic acid aptamer programmed cell-cell interactions.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Controlling Cell Interactions with DNA Directed Assembly.Advanced healthcare materials · 2024Review
- Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells.Nature chemistry · 2021Article
- MicroRNA-128 Confers Anti-Endothelial Adhesion and Anti-Migration Properties to Counteract Highly Metastatic Cervical Cancer Cells' Migration in a Parallel-Plate Flow Chamber.International journal of molecular sciences · 2020Article
- Nongenetic Bioconjugation Strategies for Modifying Cell Membranes and Membrane Proteins: A Review.Bioconjugate chemistry · 2020Review
- Review
- Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells.EBioMedicine · 2019Article
- Performing DNA nanotechnology operations on a zebrafish.Chemical science · 2018Article
- Programming Cell-Cell Interactions through Non-genetic Membrane Engineering.Cell chemical biology · 2018Review
- Engineering Reversible Cell-Cell Interactions with Lipid Anchored Prosthetic Receptors.Bioconjugate chemistry · 2018Article
- Long-term drug modification to the surface of mesenchymal stem cells by the avidin-biotin complex method.Scientific reports · 2017Article
- Dissecting the stem cell niche with organoid models: an engineering-based approach.Development (Cambridge, England) · 2017Review
- Nucleic acid aptamers: research tools in disease diagnostics and therapeutics.BioMed research international · 2014Review
- To grab the stroma by the horns: from biology to cancer therapy with mesenchymal stem cells.Oncotarget · 2013Review
- Directing the assembly of spatially organized multicomponent tissues from the bottom up.Trends in cell biology · 2012Review
- Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics.Biomaterials · 2012Article
- Chemically programmed cell adhesion with membrane-anchored oligonucleotides.Journal of the American Chemical Society · 2012Article
- Cell-surface sensors for real-time probing of cellular environments.Nature nanotechnology · 2011Article
- Cell-surface sensors: lighting the cellular environment.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Nature has evolved effective cell adhesion mechanisms to deliver inflammatory cells to inflamed tissue; however, many culture-expanded therapeutic cells are incapable of targeting diseased tissues following systemic infusion, which represents a great challenge in cell therapy. Our aim was to develop simple approaches to program cell-cell interactions that would otherwise not exist toward cell targeting and understanding the complex biology of cell-cell interactions. We employed a chemistry approach to engineer P- or L-selectin binding nucleic acid aptamers onto mesenchymal stem cells (MSCs) to enable them to engage inflamed endothelial cells and leukocytes, respectively. We show for the first time that engineered cells with a single artificial adhesion ligand can recapitulate 3 critical cell interactions in the inflammatory cell adhesion cascade under dynamic flow conditions. Aptamer-engineered MSCs adhered on respective selectin surfaces under static conditions >10 times more efficiently than controls including scrambled-DNA modified MSCs. Significantly, engineered MSCs can be directly captured from the flow stream by selectin surfaces or selectin-expressing cells under flow conditions (≤2dyn/cm²). The simple chemistry approach and the versatility of aptamers permit the concept of engineered cell-cell interactions to be generically applicable for targeting cells to diseased tissues and elucidating the biology of cell-cell interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.