ArticlemBio2011
Chromosomal rearrangements in Salmonella enterica serovar Typhi strains isolated from asymptomatic human carriers.
Article in mBio, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Prophage-mediated lysogenic conversion drives virulence evolution and genomic plasticity inMicrobiology spectrum · 2026Article
- Evolving threats: Leveraging C. elegans to decode the virulence profiles of highly related environmental Salmonella Newport isolates.PloS one · 2026Article
- Evolving Threats: LeveragingbioRxiv : the preprint server for biology · 2025Article
- Genomic diversity of non-typhoidalMicrobial genomics · 2025Article
- Complete genome of a rareMicrobiology resource announcements · 2024Article
- Salmonella enterica Serovar Typhi on an Island: No H58, No Multidrug Resistance, but for How Long?mBio · 2022Article
- Impact ofEvolution letters · 2022Article
- Mobility of antimicrobial resistance across serovars and disease presentations in non-typhoidalMicrobial genomics · 2022Article
- Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria.Molecular biology and evolution · 2022Article
- Whole genome sequence analysis of Salmonella Typhi in Papua New Guinea reveals an established population of genotype 2.1.7 sensitive to antimicrobials.PLoS neglected tropical diseases · 2022Review
- Revisiting PersistentPathogens (Basel, Switzerland) · 2021Review
- Enhanced biofilm and extracellular matrix production by chronic carriage versus acute isolates of Salmonella Typhi.PLoS pathogens · 2021Article
- Article
- Spatial and Temporal Patterns of Typhoid and Paratyphoid Fever Outbreaks: A Worldwide Review, 1990-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Review
- Persistent Infection and Long-Term Carriage of Typhoidal and Nontyphoidal Salmonellae.Clinical microbiology reviews · 2019Review
- Evolution of Salmonella within Hosts.Trends in microbiology · 2018Review
- Comparative genomics of Pseudomonas syringae pv. syringae strains B301D and HS191 and insights into intrapathovar traits associated with plant pathogenesis.MicrobiologyOpen · 2015Article
- Genomic Comparison of the Closely-Related Salmonella enterica Serovars Enteritidis, Dublin and Gallinarum.PloS one · 2015Article
- A case of adaptation through a mutation in a tandem duplication during experimental evolution in Escherichia coli.BMC genomics · 2013Article
- Salmonella enterica serovar Typhi variants in long-term carriers.Journal of clinical microbiology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Host-specific serovars of Salmonella enterica often have large-scale chromosomal rearrangements that occur by recombination between rrn operons. Two hypotheses have been proposed to explain these rearrangements: (i) replichore imbalance from horizontal gene transfer drives the rearrangements to restore balance, or (ii) the rearrangements are a consequence of the host-specific lifestyle. Although recent evidence has refuted the replichore balance hypothesis, there has been no direct evidence for the lifestyle hypothesis. To test this hypothesis, we determined the rrn arrangement type for 20 Salmonella enterica serovar Typhi strains obtained from human carriers at periodic intervals over multiple years. These strains were also phage typed and analyzed for rearrangements that occurred over long-term storage versus routine culturing. Strains isolated from the same carrier at different time points often exhibited different arrangement types. Furthermore, colonies isolated directly from the Dorset egg slants used to store the strains also had different arrangement types. In contrast, colonies that were repeatedly cultured always had the same arrangement type. Estimated replichore balance of isolated strains did not improve over time, and some of the rearrangements resulted in decreased replicore balance. Our results support the hypothesis that the restricted lifestyle of host-specific Salmonella is responsible for the frequent chromosomal rearrangements in these serovars.
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