Evidence map›Paper›PMID 21652725›Full record

ArticleEndocrinology2011

Acquisition of sexual receptivity: roles of chromatin acetylation, estrogen receptor-alpha, and ovarian hormones.

Paul J Bonthuis, James K Patteson, Emilie F Rissman

Abstract read
In one paragraph

Article in Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Exposure to Dim Light at Night Impairs Photoperiodic and Metabolic Gene Expression in Syrian Hamsters (Mesocricetus auratus).Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026
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  18. Reversible DNA methylation regulates seasonal photoperiodic time measurement.Proceedings of the National Academy of Sciences of the United States of America · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Paul J BonthuisDepartment of Biochemistry and Molecular Genetics and Neuroscience Graduate Program, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
James K Patteson
Emilie F Rissman

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008715 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LAURIE, GORDON WILLIAM · 2000 to 2019
$6.6M
GENETIC AND NEUROENDOCRINE CONTROL OF BEHAVIORAL SYSTEMSR01MH057759 · NIMH · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI RISSMAN, EMILIE F. · 1999 to 2013
$4.0M
NIGMS NIH HHS T32 GM008715NIGMS NIH HHS T32 GM08715NIMH NIH HHS R01 MH057759
6 · The paper itself

Abstract

Sexually naïve, hormone-primed, C57BL/6J female mice are not receptive to mating attempts by conspecific males. Repeated experience with sexually active males and concurrent treatment with estradiol and progesterone gradually increases female receptivity over the course of five trials to maximal levels. Ovarian hormones activate their cognate nuclear steroid receptors estrogen receptor-α and progesterone receptor to induce female sexual receptivity. Nuclear receptors recruit coactivators of transcription that include histone acetyltransferases to hormone responsive genes. In this set of studies, we found that the histone deacetylase inhibitor sodium butyrate enhances the experiential acquisition of receptivity. Evidence is provided that the actions of sodium butyrate on receptivity require activated estrogen receptor-α and progesterone.

Indexed as

Sexual Behavior, AnimalAcetylationAnimalsButyratesChromatinEstrogen Receptor alphaFemaleHistone Deacetylase InhibitorsHistonesMaze LearningMiceMice, Inbred C57BLProgesteroneButyratesChromatinEstrogen Receptor alphaHistone Deacetylase InhibitorsHistonesProgesterone

Identifiers

PMID21652725
PMCPMC3138229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.