ArticleDevelopment (Cambridge, England)2011
LMO4 functions as a co-activator of neurogenin 2 in the developing cortex.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
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- The long noncoding RNA nHOTAIRM1 is necessary for differentiation and activity of iPSC-derived spinal motor neurons.Cell death & disease · 2023Article
- Expression and role of nicotinic acetylcholine receptors during midbrain dopaminergic neuron differentiation from human induced pluripotent stem cells.Neuropsychopharmacology reports · 2023Article
- The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.Nature communications · 2022Article
- Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler.Nature neuroscience · 2022Article
- Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm.Molecular autism · 2020Article
- Necessity and Sufficiency of Ldb1 in the Generation, Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.Frontiers in molecular neuroscience · 2018Article
- Specificity of Pitx3-Dependent Gene Regulatory Networks in Subsets of Midbrain Dopamine Neurons.Molecular neurobiology · 2017Article
- RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling.Trends in cell biology · 2017Review
- Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3.Nature communications · 2015Article
- Single-cell-level spatial gene expression in the embryonic neural differentiation niche.Genome research · 2015Article
- Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization.Endocrinology · 2014Article
- Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes.PLoS genetics · 2014Article
- Article
- Lmo4 establishes rostral motor cortex projection neuron subtype diversity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- LMO4 is an essential cofactor in the Snail2-mediated epithelial-to-mesenchymal transition of neuroblastoma and neural crest cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- LIM-domain-only proteins in cancer.Nature reviews. Cancer · 2013Review
- Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
The proneural protein neurogenin 2 (NGN2) is a key transcription factor in regulating both neurogenesis and neuronal radial migration in the embryonic cerebral cortex. However, the co-factors that support the action of NGN2 in the cortex remain unclear. Here, we show that the LIM-only protein LMO4 functions as a novel co-factor of NGN2 in the developing cortex. LMO4 and its binding partner nuclear LIM interactor (NLI/LDB1/CLIM2) interact with NGN2 simultaneously, forming a multi-protein transcription complex. This complex is recruited to the E-box containing enhancers of NGN2-target genes, which regulate various aspects of cortical development, and activates NGN2-mediated transcription. Correspondingly, analysis of Lmo4-null embryos shows that the loss of LMO4 leads to impairments of neuronal differentiation in the cortex. In addition, expression of LMO4 facilitates NGN2-mediated radial migration of cortical neurons in the embryonic cortex. Our results indicate that LMO4 promotes the acquisition of cortical neuronal identities by forming a complex with NGN2 and subsequently activating NGN2-dependent gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.